The Role of COX-2 Inhibitors in Chronic Inflammatory Diseases

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorPatel, Pooja Sundip
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.date.accessioned2019-09-25T11:19:23Z
dc.date.available2019-09-25T11:19:23Z
dc.date.created2019-04-25
dc.description.abstractChronic inflammation is a slow, long term inflammation which lasts for a prolonged period, with a range from several months to years, which has now been ranked as one of the single greatest threats to human health by the World Health Organisation (WHO).In inflammatory conditions, COX-2 is increasingly produced by cytokines, growth factors and bacterial endotoxin, its enzymatic activity accounts for a large number of PGs produced during inflammation. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are nonselective inhibitors for both COX isoforms. Inhibition of COX-2 leads to therapeutic inhibition of the synthesis of proinflammatory PGs, however, this inhibition can lead to side effects. New pharmaceutical drugs which are highly selective COX-2 inhibitors, celecoxib, etoricoxib, and diclofenac, have shown to be as effective as NSAIDs with reduced side effects on various chronic inflammatory diseases, for example, rheumatoid arthritis, COPD, Parkinson, Alzheimer’s, Cardiovascular Diseases et cetera.hu_HU
dc.description.correctorLB
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent37hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/273744
dc.language.isoenhu_HU
dc.subjectCyclooxygenasehu_HU
dc.subjectCyclooxygenase 1hu_HU
dc.subjectCyclooxygenase 2hu_HU
dc.subjectNonsteroidal anti-inflammatory drugshu_HU
dc.subjectProstaglandinhu_HU
dc.subjectProstacyclinhu_HU
dc.subjectInflammationhu_HU
dc.subjectChronic Diseaseshu_HU
dc.subjectAcute Inflammationhu_HU
dc.subjectChronichu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Farmakológiahu_HU
dc.titleThe Role of COX-2 Inhibitors in Chronic Inflammatory Diseaseshu_HU
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