This research establishes a baseline for understanding of people's awareness and practices, and the use of antibiotic medications by the Syrian people, which will facilitate developing actions to address the misuse of antibiotics. Finally, the vast majority of those who took part in our research held fair awareness and practices about antibiotic usage. Unfortunately, there were a large number of participants who were taking antibiotics for improper purposes and using them incorrectly due to various factors. such as the bad economic situation and the failure to enforce laws and legislation.