Biological studies of heterobimetallic complexes as hypoxia-activated anticancer prodrugs

A tétel rövid nézete
dc.contributor.advisorSipos, Éva
dc.contributor.advisordeptGyógyszerésztudományi Kar
dc.contributor.authorEigbe, Ehiremhen Yvonne
dc.contributor.departmentDE--Gyógyszerésztudományi Kar
dc.contributor.opponentHaimhoffer, Adam
dc.contributor.opponentVarga, Balázs
dc.contributor.opponentdeptGyógyszerésztudományi Kar
dc.contributor.opponentdeptÁltalános Orvostudományi Kar
dc.date.accessioned2026-04-17T07:07:48Z
dc.date.available2026-04-17T07:07:48Z
dc.date.created2026-03-17
dc.description.abstractCancer remains a major cause of death worldwide, and while Pt(II) drugs like cisplatin are effective, their lack of selectivity leads to significant side effects. To address this, researchers are exploring alternative metal complexes with better targeting, such as Co(III) compounds that act as hypoxia-activated prodrugs. These complexes remain inactive in normal oxygen conditions but become activated in the low-oxygen environment of tumors, releasing a cytotoxic ligand derived from the iron chelator Deferiprone. In this study, newly synthesized Co(III)-based complexes and the ligand were tested on MCF-7 breast cancer cells under both normoxic and hypoxic conditions using cytotoxicity assays and RT-qPCR. Results showed that the Co(III) complex exhibited selective activation under hypoxia, with reduced toxicity in normal conditions, while the ligand induced gene expression consistent with iron chelation. Overall, the findings suggest that Co(III) complexes could serve as targeted carriers for anticancer agents, and iron chelators may also have therapeutic potential.
dc.description.coursegyógyszerész
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent40
dc.identifier.urihttps://hdl.handle.net/2437/406316
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectHypoxia-activated prodrugs
dc.subjectCobalt complexes
dc.subject.dspaceMedicine::Pharmacology
dc.titleBiological studies of heterobimetallic complexes as hypoxia-activated anticancer prodrugs
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 2 (Összesen 2)
Nincs kép
Név:
2026_03_17_1030_eigbe_ehiremhen_yvonne.pdf
Méret:
1.05 MB
Formátum:
Adobe Portable Document Format
Leírás:
Megjelenítés
Nincs kép
Név:
2026_02_13_1030_eigbe_ehiremhen_yvonne_plagiarism_statement.pdf
Méret:
225.2 KB
Formátum:
Adobe Portable Document Format
Leírás:
Megjelenítés
Engedélyek köteg
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
license.txt
Méret:
1.94 KB
Formátum:
Item-specific license agreed upon to submission
Leírás:
Letöltés
Gyűjtemények
Theses (Faculty of Pharmacy)