One health approach: dynamics of antibiotics resistance within the context of human-animal relationships

Abstract

This pilot investigation explored antibiotic resistance dynamics in the human-animal relationship, focusing on ESBL+, AmpC+, CRP+ Enterobacteriaceae, and vancomycin-resistant Enterococci. Stool samples from 19 pet-owner groups revealed that out of 128 bacterial strains, only 11 displayed the resistance mechanisms of interest, with a minor phenotypic overlap between human and pet strains. Genetic analysis confirmed phenotypic resistance but did not find identical or similar strains between humans and animals. Plasmid-encoded resistance was identified in 50% of resistant animal strains. External factors like recent hospitalization of owners might influence resistance occurrence, though the small sample size limits significant conclusions.