Procedural sedation and analgesia has become daily routine in hospitals and emergency clinics around the world, shifting the responsibility onto clinicians of all types. The typical sedatives used today, are often combined with opioid analgesics, but other potential combinations remain uncontested, which could theoretically potentiate and negate each other’s effects. These synergisms remain relatively unchallenged, and will be observed with a closes look in our pursuit for synergism. Result: It is hard to rule in favor of the Propofol-Ketamine combination, instead of monotherapy. There is additionally an increase in adverse incidences when the two drugs are given at high doses. As well as a lack of a fixed dose ratio, that could be incorporated into guidelines. It is also interesting to see that Ketamine added in sub-clinical doses PSA, elevated the patients mood post-operatively, they also felt less postprocedural pain, and experienced less hypoventilation