Students are constantly put under stress especially in medical school and this can have detrimental effects on the students’ mental and general health, even after they have graduated. This study was carried out to determine the overall mental health status of medical students at the University of Debrecen, Hungary. The research was carried out in November 2016. A random sample of medical students in their second, third, or fourth year were randomly selected and grouped. Out of 304 students who were randomly selected, 200 completely filled out the questionnaire and returned it. The response rate of the study was 66.0%, though a few questions were not filled by respondents. The research questionnaire covered questions on the social demographic, social support, general health questions, stress levels, anxiety and depression and sense of coherence of the respondents. With regards to stress within the last month of the survey, 46.5% of the respondents felt that they were unable to control the important things in their life while 5.5% felt that very often they were unable to control important things in their life. The social support and females are in positive correlation with the sense of coherence. The mean score of sense of coherence was 72.3 point and it was significantly lower in the males compared to the female. There is a clear indication that medical students at the University of Debrecen undergo significant levels of stress which in turn affects their psychological health and causes them to be less efficient.