An Atypical Antipsychotic Drug Enhances Thermogenic Capacity Of Human Cervical-Derived Adipocytes

Abstract

Adipose tissue brown/beige adipocytes express uncoupling protein 1 (UCP1) that enables them to dissipate energy as heat. Systematic activation of this process can alleviate obesity. Human brown adipose tissues are interspersed in distinct anatomical regions including deep cervical, paraspinal, and abdominal. Previous publications have reported that pharmacological compounds such as mirabegron and rosiglitazone can elevate the browning capacity of white adipocytes. Brexpiprazole is an atypical antipsychotic medication used for the treatment of major depressive disorder, schizophrenia, and agitation associated with dementia due to Alzheimer's disease. We aim to investigate the effect of long term brexpiprazole treatment on the thermogenic capacity of human subcutaneous (SC) and deep cervical (DC)-derived adipocytes.