Membrane localization of Kv1.3 channels in synapse-engaged CD19-CAR T-cells
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CAR T cells are genetically modified cells engineered to recognize CD19 on tumor cells. The immune synapse formed between a CAR T cell and a target antigen-presenting cell (APC) has unique characteristics, one of which is the accumulation of Kv1.3. By generating CAR T cells with retroviral transduction, and the activation of B cells with the engineered T cells, Kv1.3 accumulation at the synapse was captured with confocal microscopy and further analyzed with flow cytometry.
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CAR T cells, Kv1.3 channel, Immune synapse