Membrane localization of Kv1.3 channels in synapse-engaged CD19-CAR T-cells
dc.contributor.advisor | Hajdu, Péter Béla | |
dc.contributor.advisordept | Fogorvostudományi Kar | |
dc.contributor.author | Hijaz, Marwa Mahmoud Mohammad | |
dc.contributor.department | DE--Általános Orvostudományi Kar | |
dc.contributor.opponent | Mótyán , János András | |
dc.contributor.opponentdept | Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet | |
dc.date.accessioned | 2024-05-31T08:32:33Z | |
dc.date.available | 2024-05-31T08:32:33Z | |
dc.date.created | 2024-04-20 | |
dc.description.abstract | CAR T cells are genetically modified cells engineered to recognize CD19 on tumor cells. The immune synapse formed between a CAR T cell and a target antigen-presenting cell (APC) has unique characteristics, one of which is the accumulation of Kv1.3. By generating CAR T cells with retroviral transduction, and the activation of B cells with the engineered T cells, Kv1.3 accumulation at the synapse was captured with confocal microscopy and further analyzed with flow cytometry. | |
dc.description.course | molekuláris biológia | |
dc.description.courselang | angol | |
dc.description.coursespec | Biokémia-genomika | |
dc.description.degree | MSc/MA | |
dc.format.extent | 29 | |
dc.identifier.uri | https://hdl.handle.net/2437/370692 | |
dc.language.iso | en | |
dc.rights.access | Hozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében. | |
dc.subject | CAR T cells | |
dc.subject | Kv1.3 channel | |
dc.subject | Immune synapse | |
dc.subject.dspace | Biology::Immunology | |
dc.subject.dspace | Biology::Molecular Biology | |
dc.title | Membrane localization of Kv1.3 channels in synapse-engaged CD19-CAR T-cells |
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