This research examines the effect of different control substances including synthetic fungicides and biological agents like mycorrhizal preparations and a plant conditioner on corn smut disease (Ustilago maydis) and the subsequent growth and yield of maize. The primary objective was to assess the efficacy of these treatments in managing the disease and their influence on key physiological parameters, specifically crop height and grain yield. The study employed a controlled experimental methodology where artificially inoculated corn plants were subjected to different treatments. Growth indicators, namely plant height and grain yield, were meticulously measured, and statistical analysis was utilized to determine the significance of treatment outcomes. The findings revealed that while many treatments did not significantly alter overall growth, Treatment 2, a combination of mycorrhiza and a plant conditioner, demonstrated potential for maximizing crop height and simultaneously managing corn smut infestation. Notably, the synthetic fungicide treatment (T4) emerged as the most effective strategy for increasing crop yield, although this effect was accompanied by some variability. Furthermore, the study emphasized the important influence of weather conditions on both the development of corn smut disease and the overall effectiveness of applied control treatments. In conclusion, the research suggests that a combined approach utilizing mycorrhizal preparations and plant conditioners hold promises for effectively controlling corn smut while also promoting maize plant growth. However, the study underscores the necessity for further research to validate these initial findings and to explore the long-term sustainability and broader applicability of these treatments under diverse environmental conditions. The substantial influence of weather patterns on disease dynamics and treatment efficacy necessitates attention in future research and the formulation of effective management methods.