The pharmacotherapy of endometriosis

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Endometriosis is a disease defined by the presence of endometrial tissue in ectopic locations. It is a debilitating disease of which the pathogenesis is not fully understood. It affects about 10-15% of women of reproductive age and 70% of women with chronic pelvic pain. Understanding the pathogenesis and biological processes that result in the symptoms of endometriosis highlights the possible targets for treatment by pharmacological means. Drugs such as GnRH agonists, Danazol, Gestrinone, and newer drugs like GnRH antagonists target the increased estrogen production, which is a critical factor in the pathogenesis and survival of endometrial lesions. Aromatase inhibitors decrease the intrinsic aromatase activity of endometriotic lesions. NSAIDs alleviate the dysmenorrhea and non-cyclical pelvic pain associated with endometriosis. Progestogens and oral contraceptives combat the apparent resistance to progesterone in endometrial lesions. This article delves into the significant characteristics of the current medications used in the pharmacotherapy of endometriosis, their mechanism of action, side effects, and dosage, as well as the possible future ones.

endometriosis, pharmacotherapy, gynecology