Antiarrythmic treatment for inherited arrythmia

Abstract

Inherited arrythmia is arrythmia caused by genetic disorder which disrupt the electrical activity of the heart. They cause life threatening cardiac event such as syncope, seizure, and sudden cardiac death. They include Long QT syndrome, short QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia. Genetic mutations in ion channel genes and associated pathways form the basis of arrhythmogenesis, leading to abnormal cardiac excitability and conduction. This thesis starts with physiology of heart conduction system, which is important to understand arrythmia, and any type of arrythmia. Also this thesis explore the pathophysiology, diagnosis, and treatment of inherited arrythmias, emphasizing the critical role of interdisciplinary care in managing these conditions.