The pharmacological management of inflammatory diseases : Comparing NSAIDs with novel anti-inflammatory agents

dc.contributor.advisorPorszász, Róbert
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorHong, Sun Ho
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentSzentmiklósi, József
dc.contributor.opponentHalasi, Barbara Dóra
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Igazságügyi Orvostani Intézet
dc.date.accessioned2026-04-15T10:02:38Z
dc.date.available2026-04-15T10:02:38Z
dc.date.created2026-02-17
dc.description.abstractThis thesis reviews the pharmacological management of inflammatory diseases by comparing traditional non-steroidal anti-inflammatory drugs (NSAIDs) with novel targeted anti-inflammatory agents. It outlines key inflammatory pathways and mediators, including cyclo-oxygenase-derived prostaglandins and major cytokine signaling networks. NSAIDs are discussed in terms of mechanical of action, clinical indications, and limitations related to gastrointestinal, renal and cardiovascular adverse effects. The thesis then summarizes newer therapies such as biological targeting TNF-alpha and interleukin pathways, as well as Janus kinase (JAK) inhibitors. Their benefits in disease control and prevention of structural damage are contrasted with safety considerations, monitoring requirements, and cost. Overall, NSAIDs remain first line for acute pain and short term inflammatory symptoms, whereas targeted therapies are preferred for chronic immune mediated diseases requiring sustained disease modification.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent38
dc.identifier.urihttps://hdl.handle.net/2437/406250
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectNSAIDs
dc.subjectBiologics
dc.subjectJAK inhibitors
dc.subject.dspaceMedicine::Pharmacology
dc.titleThe pharmacological management of inflammatory diseases : Comparing NSAIDs with novel anti-inflammatory agents
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