Preformulation studies of curcumin with a PEG gamma cyclodextrin polymer

Abstract

This study focuses on the ability of a PEG gamma cyclodextrin polymer to be a drug vehicle that may result in solubility and stability increase of poorly water-soluble drugs, such as curcumin. The study has been conducted due to the inability of curcumin to dissolve well in water, which also prevents its delivery and effectiveness as a drug. The problem of the research is the necessity of advanced drug delivery systems that help make poorly soluble and unstable drugs to be soluble. This technique involves the chemical incorporation of cyclodextrin and the incorporation of curcumin into the cyclodextrin chain. The in vitro studies were performed in order to examine the drug's efficiency in microparticles made of polymers as well as to understand the product compatibility of the polymer and PVA for delivery purposes. The study substantiated the most shown increase in curcumin solution that was encapsulated in the polymer along with the interaction of the polymer with mucin and the feasibility of PVA for the drug-carrying films. The research outcome could involve the design of indefinite-release dosage forms and extended-release medications for those drugs that are poorly soluble in water.