Ischemic heart disease also known as coronary heart disease or coronary artery disease is one of the top rated medical concerns nowadays. It develops in the coronary by the narrowing of those ones. Hence, it suddenly or gradually reduces the blood flow in the coronary to the myocardium. Since the beginning of 20th century the occurrence of unknown ischemia event has be reduced. In third world countries, the disease could still have huge impact in the following years since the medications usually to manage those conditions are really expensive and this might result in a shift in balance to their budget.With recent development in the diagnostic method such as PET, MRI, Echo, ECG and Angiography can help us determine if the certain patient is prone to have the condition, and even the degree to which the vessel is occluded. The ACC/AHA provided protocols that can be followed and most of them either included invasive and surgical procedures like (CABG, opened chest surgery) and non- surgical procedures like PCI (balloon angioplasty, placement of the stent) , a medical approach with the use of Aspirin, antianginal drugs, beta blockers, CCB, diuretics, statins and even nitrates. According to the ACC/AHA, the therapy concerning each disease in the IHD family had to follow a certain protocol, while stable angina could be controlled easily with a medical therapy and a primordial use of sublingual nitrates, aspirin and PCI, symptoms of the ACS (UA, NSTEMI and STEMI) have a tougher time being treated since they can appear at any time of the day, and the psychological repercussion after been gone through a close to fatal MI can lead to a severe depression that has another path of treatment.