Multiparticulate dosage forms are gaining increased favor over single-unit dosage forms because of their potential benefits, such as predictable gastric emptying, lower risk of dose dumping, flexible release patterns, increased bioavailability, less irritation of the gastrointestinal tract, better flow properties, a less friable dosage form, narrow particle size distribution, and ease of coating.

The main advantage of extrusion-spheronisation over other techniques includes the ability to incorporate higher levels of active components without producing excessively large particles, and two or more active agents can be easily combined in any ratio in the same unit.

The aim of this research is to determine the optimal parameters of the extruder, namely, the screw rotation speed, liquid addition rate and powder feeding rate, to determine the independent process parameters of the spheroniser, and to measure the loss-on-drying values, particle size distribution, and morphology of extrudates.

The required machines to produce pellets are a twin-screw extruder, a spheroniser, a peristaltic pump, and a cooling system. The moisture content of the extrudates was measured using the loss-on-drying method. For additional experiments, a particle size distribution machine and scanning electron microscopy were used.