Insulin resistance is a condition of hyperinsulinemia due to the unresponsiveness of the target tissues to insulin. Despite the high levels of insulin, insulin sensitive cells fail to take up glucose resulting in a vicious loop. These effects are mainly due to chronic low-grade inflammation, which is maintained by the enlarged white adipose tissue (WAT) secreting biologically active adipo(cyto)kines. In addition to the adipokines, enhanced secretion of other bioactive lipids, signaling proteins, hormones and transcription factors also results in insulin resistance. Non-alcoholic fatty liver disease (NALFD), or as it is recently termed metabolic dysfunction-associated fatty liver disease (MAFLD) is a condition with increased lipid deposition in the hepatocytes (steatosis) that may lead to steatohepatitis, as well.If left untreated, the inflammation eventually leads to fibrosis and cirrhosis of the liver, which is then classified as NASH (non-alcoholic steatohepatitis). Both insulin resistance and NAFLD are heavily associated with metabolic syndrome, obesity, T2DM (type 2 diabetes mellitus), sedentary lifestyle, and hyperlipidemia.