Fibre Guiding Scaffolds For Periodontal Tissue Engineering

dc.contributor.advisorVarga, István
dc.contributor.advisordeptDebreceni Egyetem::Fogorvostudományi Kar::Parodontológiai Tanszékhu_HU
dc.contributor.authorNguyen, Duy Anh
dc.contributor.departmentDE--Fogorvostudományi Karhu_HU
dc.contributor.opponentAngyal, János
dc.contributor.opponentSkopkó, Boglárka Emese
dc.description.abstractThis thesis reports recent innovations in stem cells, 3D printing, and layered biomaterial for the regeneration of bone, cementum, PDL, and bone-cementum-PDL complex. First, cell-homing was developed to circumvent the ethical issues associated with utilizing embryonic stem cells and reduce the risk of immunological rejection related to foreign cell transplantation. Secondly, 3D printing produced innovative scaffolds with customized biomimetic architectures and bioactive components more easily and reliably. Third, gene therapy could improve periodontal regeneration by carefully targeting the regulation of the defect of the microenvironment. Finally, combinational techniques for healing the bone-PDL-cementum system have been devised by establishing multiphasic components and cells to restore periodontal compartments synchronously, biomimetically, and entirely. The alternative techniques for fabricating fibre guiding scaffolds, such as Electrospun Fibers, Additive Manufacturing, the Soft Lithography method, and their periodontal regeneration capacity in animal models, have been reported.hu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.subjectTissue engineeringhu_HU
dc.subjectPeriodontal regenerationhu_HU
dc.subjectPeriodontal scaffoldhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Fogorvostudományhu_HU
dc.titleFibre Guiding Scaffolds For Periodontal Tissue Engineeringhu_HU