Volume regulated anion channels in the regulation of endothelial proliferation

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorAlmegati, Abdullah Talal M
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2019-09-25T11:06:40Z
dc.date.available2019-09-25T11:06:40Z
dc.date.created2018-09-07
dc.description.abstractCells regulate their volume to counteract swelling or shrinkage caused by osmotic challenges and during processes such as cell growth, division, and migration. As water transport across cellular membranes is driven by osmotic gradients, cell volume regulation requires appropriate changes of intracellular concentrations of ions or organic osmolytes such as taurine. Regulatory volume decrease (RVD) follows the extrusion of intracellular Cl – and K+ and other osmolytes across the plasma membrane. VRAC plays a major role in water transport during volume regulation. Inhibition of VRAC reduces water permeability of the cell membrane of endothelial cells indicating that VRAC might be permeable for water and can be considered as a “wet” channel.hu_HU
dc.description.correctorLB
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent46hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/273739
dc.language.isoenhu_HU
dc.subjectvolume regulatedhu_HU
dc.subjectanion channelshu_HU
dc.subjectregulationhu_HU
dc.subjectendothelialhu_HU
dc.subjectproliferationhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleVolume regulated anion channels in the regulation of endothelial proliferationhu_HU
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