Systemic lupus erythematosus (SLE) is an autoimmune disease that has multiple characteristic symptoms affecting almost every organ system in the body. Pediatric-onset SLE accounts for 10-20% of all SLE cases, with the age of disease occurring most frequently between the ages of 12 and 16 years. Clinical features and specific laboratory data are needed to diagnose LN. Once LN has accurately been identified, a renal biopsy must be performed to further classify the extent of LN. The classification can help to estimate the prognosis of disease, as well as give incite to the individualized treatment options. Most therapies of LN include a strong induction dosage of steroids and immunosuppressants at the onset of disease, and continuous maintenance therapy through the patient’s lifetime.