Angina pectoris is a clinical syndrome characterized by episodes of chest pain. It occurs when there is a deficit in myocardial oxygen supply in relation to myocardial oxygen demand. It is most often caused by atherosclerotic plaque in the coronary arteries but may also be caused by coronary vasospasm. The development and progression of atherosclerotic plaque is called coronary artery disease. Treatment of angina pectoris consists of drug administration and revascularisation. Long-lasting agents such as nitroglycerin, beta blockers, and calcium channel blockers are the first line drugs. They can be administered in monotherapy or in combination. ACE inhibitors, statins, and aspirin are given in order to reduce the risk of heart attack and stroke in patients with angina. New drugs like Ivabradine, Ranolazine, Trimetazidine, and Fasudil act on alternative ways and provide releaving symptoms of angina.