An overview on ischemia-reperfusion, ischemic pre- and postconditioning with their microcirculatory relations

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dc.contributor.advisorNémeth, Norbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézet::Sebészeti M?téttani Tanszékhu_HU
dc.contributor.authorAvgoustidis, Andreas Alexandros
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentkereszty, Zsolt
dc.contributor.opponentKiss, Ferenc
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézethu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézet::Sebészeti M?téttani Tanszékhu_HU
dc.date.accessioned2014-07-29T13:27:56Z
dc.date.available2014-07-29T13:27:56Z
dc.date.created2013-05-21
dc.description.abstractThe main aim of this thesis was to provide a systematic review of the complex pathophysiology of ischemia-reperfusion injury, and its effect on blood rheology and on the microcirculatory system. The phenomenon of ischemia-reperfusion injury is commonly witnessed in organ transplantation, major organ surgical resections and after shock, causing harmful local and systemic outcomes, and is associated with a high incidence of morbidity and mortality. Ischemic preconditioning, one of the most potent procedures that emerged to counteract ischemia-reperfusion injury, allows tissues to adapt and become tolerant to such conditions. Research has also more recently been conducted on a similar technique termed ischemic postconditioning, in which we have seen that timing to reperfusion is the key. Remote ischemic preconditioning, after application of brief ischemia-reperfusion cycles in a single organ, was found to provide systemic protection from a subsequent extensive period of ischemia. Similarly, remote ischemic postconditioning has also evolved as a protective measure. Ischemia-reperfusion affects the state of blood flow, at the microcirculatory level in many ways. However, the interactions between hemodynamic characteristics and alterations in hemorheology are complex and the effects of ischemia-reperfusion injury are difficult to determine because rheological properties of multiple blood elements are influenced simultaneously, each affecting different aspects of its rheological behavior, in turn.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent34hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/195473
dc.language.isoenhu_HU
dc.subjectIschemia-reperfusionhu_HU
dc.subjectIschemic preconditioninghu_HU
dc.subjectIschemic postconditioninghu_HU
dc.subjectMicrocirculationhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Sebészethu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Műtéttanhu_HU
dc.titleAn overview on ischemia-reperfusion, ischemic pre- and postconditioning with their microcirculatory relationshu_HU
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Gyűjtemények
Theses (Faculty of Medicine)