Synthesis of Galactocluster-Fluorquinolone Chimera Antibiotic

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dc.contributor.advisorCsávás, Magdolna
dc.contributor.advisordeptDebreceni Egyetem::Gyógyszerésztudományi Karhu_HU
dc.contributor.authorTran, Tu
dc.contributor.departmentDE--Gyógyszerésztudományi Karhu_HU
dc.contributor.opponentZita Tunde Tothne, Illyes
dc.contributor.opponentTósaki, Árpád
dc.contributor.opponentdeptDebreceni Egyetem::Gyógyszerésztudományi Karhu_HU
dc.date.accessioned2021-05-03T12:45:04Z
dc.date.available2021-05-03T12:45:04Z
dc.date.created2021-03-02
dc.description.abstractThe continual lung infection caused by Pseudomonas aeruginosa in most cystic fibrosis cases is nowadays a major concern. Multiresistance has made the production of new antibiotics an urgent necessity. A new synthetic idea of the possible antibiotic structure in which ciprofloxacin is attached to a trivalentgalactose cluster has been generated by our understanding of the relationship between bacterial lectin PA-IL and D-galactose. The method is to use a series of cupper-mediated azide- alkyne “click” reaction to join together propargylatedtetraethyelene bridges, scaffold, sugar (D- galactose) and finally, the antibiotics itself.hu_HU
dc.description.coursegyógyszerészhu_HU
dc.description.courselangangolhu_HU
dc.description.coursespecBiokémia-genomikahu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent30hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/308186
dc.language.isoenhu_HU
dc.subjectChimera Antibiotichu_HU
dc.subject.dspaceDEENK Témalista::Kémiahu_HU
dc.titleSynthesis of Galactocluster-Fluorquinolone Chimera Antibiotichu_HU
dc.title.subtitleSynthesis of Galactocluster-Fluorquinolone Chimera Antibiotichu_HU
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Theses (Faculty of Pharmacy)