This thesis on old and new approaches to treatment diabetes mellitus type 1 aims at giving an insight at various aspects of this chronic disease management. Type 1 diabetes mellitus (T1DM), is autoimmune chronic disease characterized by insulin deficiency due to pancrea1c β-cell loss which leads to hyperglycemia. Onset is usually during childhood or adolescence. A cure is not available although, T1DM can be controlled with lifestyle adjustments and medical treatments. Keeping blood sugar levels under control can prevent or minimize complica1ons in the futures