In utero nutrition: long-term effect on performance in sheep

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dc.contributor.advisorBabinszky, László
dc.contributor.advisorDerancourt, Michel
dc.contributor.authorHansen, Pernille Willert
dc.contributor.departmentDE--Mezőgazdaság- Élelmiszertudományi és Környezetgazdálkodási Karhu_HU
dc.date.accessioned2014-09-12T09:29:32Z
dc.date.available2014-09-12T09:29:32Z
dc.date.created2014
dc.description.abstractClimate changes and increasing temperatures is going to increase the incidence for fetal programming in sheep. Recognizing the importance of in utero nutrition might help to sustain small ruminant production in the future. The adverse impact of fetal programming for performance in lambs have already been assessed, and expandability of the subcutaneous adipose has earlier been found to be a main target of fetal programming, causing metabolic dysfunction. The aim of this study was to clarify the importance of in utero nutrition in animal nutrition science by investigating the long-term effect of fetal programming on performance in adult sheep and to investigate whether the subcutaneous adipose tissue was still a main target. Body measurements, carcass characteristics, the subcutaneous adipose tissue and plasma metabolites were analyzed in 2½ year old sheep exposed to either prenatal under- (LOW) or overnutrition (HIGH) or adequately fed (NORM) and subsequently exposed to early postnatal diets until 6 months of age: either a high carbohydrate-high fat (HCHF) or conventional diet (CONV). The major findings were that there was a long-term effect of the prenatal diet into adulthood, irrespective of an adverse early postnatal diet. An effect of the early postnatal diet was still evident even after a dietary correction later in life, and a mismatched pre- and postnatal diet also turned out to have long lasting effects. The subcutaneous adipose tissue was still a target of fetal programming, though no longer by impaired expandability, but by an up-regulation of VEGF-A expression. More knowledge is required on the specific critical periods during gestation where productivity can be affected and about the transgenerational effect of fetal programming in sheep and from there, in utero nutrition can become a tool to optimize sheep production in the future.hu_HU
dc.description.courseSustainable Animal Nutrition and Feeding MSc programhu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent53hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/196433
dc.language.isoenhu_HU
dc.rightsNevezd meg! - Ne add el! - Ne változtasd! 2.5 Magyarország*
dc.rightsNevezd meg! - Ne add el! - Ne változtasd! 2.5 Magyarország*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/hu/*
dc.subjectIn utero nutrition, fetal programming, long-term effect, performance,adult sheep, subcutaneous adipose tissuehu_HU
dc.subject.dspaceDEENK Témalista::Mezőgazdaságtudomány::Állattenyésztéstanhu_HU
dc.titleIn utero nutrition: long-term effect on performance in sheephu_HU
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Hallgatói dolgozatok (Mezőgazdaság-, Élelmiszertudományi és Környezetgazdálkodási Kar)