Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity

A tétel rövid nézete
dc.contributor.authorJuhász, Marianna
dc.contributor.authorMolnár, Levente
dc.contributor.authorFülesdi, Béla
dc.contributor.authorVégh, Tamás
dc.contributor.authorPáll, Dénes
dc.contributor.authorMolnár, Csilla
dc.contributor.authorVégh Tamás (1975-) (aneszteziológus, intenzív terápiás szakorvos)
dc.contributor.submitterdepAneszteziológiai és Intenzív Terápiás Tanszék -- 70
dc.contributor.submitterdepÁOK
dc.contributor.submitterdepDebreceni Egyetem
dc.date.accessioned2019-06-29T10:12:46Z
dc.date.available2019-06-29T10:12:46Z
dc.date.oa2019-07-16
dc.date.updated2019-06-29T10:12:46Z
dc.description.abstractBackground: Sevoflurane is one of the most frequently used inhaled anesthetics for general anesthesia. Previously it has been reported that at clinically used doses of sevoflurane, cerebral vasoreactivity is maintained. However, there are no data how sevoflurane influences systemic and cerebral circulation in parallel. The aim of our study was to assess systemic and cerebral hemodynamic changes as well as cerebral CO2-reactivity during sevoflurane anesthesia. Methods: Twenty nine patients undergoing general anesthesia were enrolled. Anesthesia was maintained with 1 MAC sevoflurane in 40% oxygen. Ventilatory settings (respiratory rate and tidal volume) were adjusted to reach and maintain 40, 35 and 30 mmHg EtCO2 for 5 min respectively. At the end of each period, transcranial Doppler and hemodynamic parameters using applanation tonometry were recorded. Results: Systemic mean arterial pressure significantly decreased during anesthetic induction and remained unchanged during the entire study period. Central aortic and peripherial pulse pressure and augmentation index as markers of arterial stiffness significantly increased during the anesthetic induction and remained stable at the time points when target CO2 levels were reached. Both cerebral autoregulation and cerebral CO2-reactivity was maintained at 1 MAC sevoflurane. Discussion: Cerebral autoregulation and CO2-reactivity is preserved at 1 MAC sevoflurane. Cerebrovascular effects of anesthetic compounds have to be assessed together with systemic circulatory effects. Trial registration: The study was registered at http://www.clinicaltrials.gov, identifier: NCT02054143, retrospectively registered. Date of registration: February 4, 2014. Keywords: Sevoflurane, Cerebral blood flow, cerebral autoregulation, CO2-reactivity, applanation tonometry, Transcranial Doppler
dc.description.correctorLB
dc.identifier.citationBMC Anesthesiology. -19 : 1 (2019), p. 109-116. -BMC Anesthesiol. -1471-2253
dc.identifier.doi10.1186/s12871-019-0784-9
dc.identifier.issn1471-2253
dc.identifier.opachttp://webpac.lib.unideb.hu:8082/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM079554
dc.identifier.urihttp://hdl.handle.net/2437/270114
dc.identifier.urlhttps://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-019-0784-9
dc.languageeng
dc.rights.accessopen access journal
dc.subject.otheridegen nyelvű folyóiratközlemény külföldi lapban
dc.subject.otherSevoflurane, Cerebral blood flow, cerebral autoregulation, CO2-reactivity, applanation tonometry, Transcranial Doppler
dc.titleEffect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity
dc.typefolyóiratcikk
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
FILE_UP_1_Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity.pdf
Méret:
968.43 KB
Formátum:
Adobe Portable Document Format
Leírás:
Kiadói változat
Letöltés
Gyűjtemények
Publikációs Adatbázis