New advances in the antiretroviral therapy

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorSiddiqui, Zain ul Abdin
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentMegyeri, Attila
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.opponentdeptKenézy Kórház Aneszteziológiai és Intenziv Therápiás Osztályhu_HU
dc.date.accessioned2022-08-17T08:32:45Z
dc.date.available2022-08-17T08:32:45Z
dc.date.created2022
dc.description.abstractToday, the standard of care for HIV management is the combination antiretroviral therapy, which utilizes multiple antiretrovirals from various classes to achieve long-term viral suppression. This is a highly effective technique for treating infection and preventing virus transmission. The range of antiretroviral therapy has expanded as a consequence of extensive research into viral pathogenesis. The inclusion of novel antiretroviral agents, particularly first-in-class inhibitors, reflects a paradigm shift towards the identification of compounds that act on new viral targets during the replication cycle. Despite such advanced treatment choices, some obstacles remain in terms of safety profiles, drug adherence, and affordability. For these very reasons, research is still ongoing to discover drugs that can be delivered alternatively to per os, to formulate simplified drug regimens such as 2-drug combinations, to identify long-acting drugs with improved pharmacokinetic properties, and to develop investigational drugs, all of which will help improve adherence and increase the overall efficacy of antiretroviral therapy. Future options might include latency-reversing drugs, broadly neutralizing antibodies, and therapeutic vaccines, which would help further optimize antiretroviral therapy by assisting in achieving a functional cure.hu_HU
dc.description.correctorhbk
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent45hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/336530
dc.language.isoenhu_HU
dc.subjectAntiretroviralshu_HU
dc.subjectHIVhu_HU
dc.subjectNovel therapieshu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleNew advances in the antiretroviral therapyhu_HU
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