The effects and molecular targets of butyrate in the differentiation of human monocyte-derived dendritic cells

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dc.contributor.advisorBene, Krisztián
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Immunológiai Intézethu_HU
dc.contributor.authorTóth, Lehel József
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentCzimmerer, Zsolt
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézethu_HU
dc.date.accessioned2019-06-04T11:20:01Z
dc.date.available2019-06-04T11:20:01Z
dc.date.created2019
dc.description.abstractDendritic cells (DC) form an important part of the immune system by initiating and orchestrating antigen specific immune responses against microbes and tumors. The gastrointestinal lumen is lined with countless microorganisms forming the human gut microbiota. Among these microorganisms are the resident anaerobic microbes which can ferment indigestible plant fibers into Short-Chain Fatty Acids (SCFA). Previous studies have confirmed the protective effects of butyrate on the immune system, however the effects and molecular targets of butyrate on the differentiation of monocyte-derived dendritic cells (moDC) are still unknown. In this study we aimed to uncover butyrate-induced cell signaling pathways which may affect DC differentiation.hu_HU
dc.description.correctorhbk
dc.description.courseorvosi laboratóriumi és képalkotó diagnosztikai analitikushu_HU
dc.description.courseactnappalihu_HU
dc.description.courselangmagyarhu_HU
dc.description.coursespecOrvosi kutatólaboratóriumi analitikahu_HU
dc.description.degreeBSc/BAhu_HU
dc.format.extent28hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/268659
dc.language.isoenhu_HU
dc.subjectMonocyte derived dendritic cellhu_HU
dc.subjectButyratehu_HU
dc.subjectDentritic cellhu_HU
dc.subjectSCFAhu_HU
dc.subjectPPARhu_HU
dc.subject.dspaceDEENK Témalista::Biológiai tudományok::Immunológiahu_HU
dc.titleThe effects and molecular targets of butyrate in the differentiation of human monocyte-derived dendritic cellshu_HU
dc.title.translatedA butyrate hatásai és molekuláris célpontjai humán dendritikus sejtekbenhu_HU
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Hallgatói dolgozatok (Általános Orvostudományi Kar)