Diarrhea is one of the leading causes of children under five years old morbidity and mortality in Indonesia. Children characteristics, immune protection program, hygiene and sanitation, socio economic and geographic determinants were analysed by multivariate logistic regression in detecting the potential association and controlling confounding effects within the variables towards diarrhea occurrence. Supporting breastfeeding program, safely disposal stool practice and treated drinking water need to be strengthened in Indonesian diarrhea prevention priorities.