Synthesis and Characterization of Co(III) Complexes as Potential Hypoxia-activated Prodrugs

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dc.contributor.advisorBuglyó, Péter
dc.contributor.authorSulieman, Bashir
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Kémiai Intézethu_HU
dc.date.accessioned2015-12-08T10:04:57Z
dc.date.available2015-12-08T10:04:57Z
dc.date.created2015-11-19
dc.description.abstractCo(III) complexes are known as inert (characterized by slow ligand exchange) but after reduction, the Co(II) state that is formed is labile (fast ligand exchange). Hypoxia as a common feature of cancer tissues means lack of adequate oxygen level, therefore a more reductive environment. When administered, rationally designed Co(III) complexes may be reduced selectively in these tissues and therefore may serve as carrier of drug molecules that are capable of killing cancer cells because the reduction and the release of the drug is more pronounced in the cancer cells. The type of drug molecules can be hydroxamic acids with proven anticancer activity.hu_HU
dc.description.correctorgj
dc.description.courseChemical engineeringhu_HU
dc.description.degreeBSc/BAhu_HU
dc.format.extent22hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/220228
dc.language.isoenhu_HU
dc.subjectSynthesishu_HU
dc.subjectCharacterization of Co(III)hu_HU
dc.subjectPotential Hypoxia-activated Prodrugshu_HU
dc.subject.dspaceDEENK Témalista::Kémia::Szervetlenkémiahu_HU
dc.titleSynthesis and Characterization of Co(III) Complexes as Potential Hypoxia-activated Prodrugshu_HU
dc.title.translatedSynthesis and Characterization of Co(III) Complexes as Potential Hypoxia-activated Prodrugshu_HU
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Hallgatói dolgozatok (Természettudományi és Technológiai Kar)