Intraoral bone defects in maxillofacial patients can result from conditions such as tumor resection, cysts, trauma, congenital anomalies, and osteonecrosis, significantly affecting mastication, speech, appearance, and quality of life. These defects require complex prosthetic rehabilitation to restore oral function and esthetics. Modern prosthetic solutions include removable, fixed, or implant-supported devices tailored to individual patient needs. Obturators, palatal lift prostheses, and speech aids help restore separation between oral and nasal cavities, improving swallowing, speech, and chewing. In cases of severe bone loss, zygomatic and pterygoid implants provide reliable alternatives when conventional implants are not feasible. Additionally, CAD/CAM technology has enhanced the precision, fit, and efficiency of prosthetic rehabilitation, improving functional and aesthetic outcomes while reducing fabrication errors.