IV anesthetics is an important category of fast and short-acting agents that seemed to cause diminished perception or full sedation. Frequently used IV anesthetics include barbiturates, propofol, and etomidate. A fast-acting anesthetic with hypnotic effects on the reticular development of GABA receptors. Often used general anesthesia induction has less cardiac impact compared to other IV anesthetics. Propofol is the traditional anesthesia induction drug that is most commonly given in patients with hemodynamic issues and instability. Ketamines have a major role in urgent cases due to their strong impact as a sympathomimetic and analgesic agent. Thiopental decreases the pressure intracranially, which makes it crucial in patients with head trauma as well as those who have elevated intracranial pressure. While the side effects of IV anesthetics are highly dependent on the agent involved and used, they all have a clear hypnotic as well as sedative effect.