Egészségügyi Innovációs Szemle (DE-journals)
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Egészségügyi Innovációs Szemle (DE-journals) Szerző szerinti böngészés "Bácskay, Ildikó"
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Tétel Szabadon hozzáférhető Ciklodextrinek szerepe a COVID-19 elleni küzdelemben(2022-07-18) Réti-Nagy, Katalin; Bácskay, Ildikó; Vecsernyés, Miklós; Fenyvesi, FerencSince the emergence of the SARS-CoV-2 virus in late 2019, several therapeutic possibilities have appeared to treat patients who are often in severe condition due to the pathogen. As more information becomes available about the virus, the therapeutic strategies can be more specific. Cyclodextrins are well known molecules in the pharmaceutical industry. Due to their special structure they can be widely used in drug development. One of our main research topic is the application of cyclodextrins, so considering the current pandemic situation, it was relevant for us to summarize the role of cyclodextrin molecules in the therapy of COVID-19 disease. In the course of our literary research, we have found many interesting theories and promising developments.Tétel Szabadon hozzáférhető Formulation of Novel Liquid Crystal (LC) Formulations with Skin-Permeation-Enhancing Abilities of Plantago lanceolata (PL) Extract and Their Assessment on HaCaT Cells(Health Innovation Review) Kósa, Dóra; Pető, Ágota; Fenyvesi, Ferenc; Váradi, Judit; Vecsernyés, Miklós; Gonda, Sándor; Vasas, Gábor; Fehér, Pálma; Bácskay, Ildikó; Ujhelyi, ZoltánTétel Szabadon hozzáférhető Hidroxi-propil-béta-ciklodextrin celluláris internalizációjának és lizoszómákra gyakorolt hatásának vizsgálata(2023-07-15) Rusznyák, Ágnes; Réti-Nagy, Katalin; Váradi, Judit; Bácskay, Ildikó; Vecsernyés, Miklós; Fenyvesi, FerencCyclodextrins are widely used excipients to increase water solubility and bioavailability of lipophilic drugs. Our research group previously showed that cyclodextrins are able to enter Caco-2 intestinal epithelial cells by endocytosis, however, the cellular internalization and intracellular effects in the case of different cells have not been investigated yet. In addition, 2-hydroxypropyl-beta-cyclodextrin (HPBCD) is a potential molecule for the treatment of Niemann Pick syndrome type C due to its cholesterol complexing properties. The aim of our work is to investigate and compare the cellular internalization of HPBCD and its effect on lysosomes on Caco-2 intestinal epithelial, HeLa cervical epithelial and hCMEC/D3 brain endothelial cells.Tétel Szabadon hozzáférhető Prebiotikum tartalmú kapszulák formulálása és vizsgálata(2022-07-18) Bácskay, Ildikó; Újhelyi, Zoltán; Pető, Ágota; Kósa, Dóra; Józsa, Liza; Vasas, Gábor; Zsuga, Judit; Siposné Fehér, PálmaPrebiotics are non-digestible food ingredients that reach the colon unchanged, serving as nutrients for bacterial strains that are beneficial to the body and helping them to multiply. The aim of the present experimental work was to formulate a capsule with a prebiotic composition. The capsule composition was formulated from different prebiotics: inulin, galacto-oligosaccharide, pectin. In addition to prebiotics, the product contains zinc citrate. The pharmacopoeia and other dosage form test of the powder mixture and capsules were examined. The average weight of the capsules, the uncompressed and compressed density of the capsule filling, the particle size distribution by sieve analysis and the fluidity of the powder mixture were determined. In addition, the homogeneous distribution of zinc citrate in the powder mixture was investigated using an analytical method. The results of the tests confirmed that the composition is technologically appropriate. The chosen manufacturing technology and sequence of operations ensure a homogeneous distribution of components and the reproducibility.Tétel Szabadon hozzáférhető Role of cyclodextrins in therapeutic strategies of COVID-19(Health Innovation Review) Réti-Nagy, Katalin; Bácskay, Ildikó; Vecsernyés, Miklós; Fenyvesi, FerencTétel Szabadon hozzáférhető Szájban diszpergálódó gyógyszerformák: alkalmazási és előállítási lehetőségek(2023-07-15) Dávid, Sinka; Doma, Enikő; Varga, Mercédesz; Bácskay, IldikóTaking several aspects into account, it can be stated that oral dosage forms are the preferred in pharmacotherapy. Depending on the needs and limitations of different patient groups, pharmaceutical technology offers several options for oral administration. Different types of preparations have different advantages and, of course, disadvantages, and in many cases different production needs. Orally dispersible solid pharmaceutical preparations can themselves be divided into several groups, and in the case of specific groups of active ingredients, a significant increase in bioavailability and patient compliance can be achieved with their use. However, they must meet several specific conditions during their formulation.Tétel Szabadon hozzáférhető Új típusú Plantago lanceolata (PL) tartalmú folyadékkristályos rendszerek (LC) formulálása és jellemzése HaCaT sejtvonalon(2022-07-15) Kósa, Dóra; Pető, Ágota; Fenyvesi, Ferenc; Váradi, Judit; Vecsernyés, Miklós; Gonda, Sándor; Vasas, Gábor; Fehér, Pálma; Bácskay, Ildikó; Ujhelyi, ZoltánExposure to reactive oxygen species can easily result in serious diseases, such as hyperproliferative skin disorders or skin cancer. Herbal extracts are widely used as antioxidant sources in different compositions. The importance of antioxidant therapy in inflammatory conditions has increased. Innovative formulations can be used to improve the effects of these phytopharmacons. The bioactive compounds of Plantago lanceolata (PL) possess different effects, such as anti-inflammatory, antioxidant, and bactericidal pharmacological effects. The objective of this study was to formulate novel liquid crystal (LC) compositions to protect Plantago lanceolata extract from hydrolysis and to improve its effect. Since safety is an important aspect of pharmaceutical formulations, the biological properties of applied excipients and blends were evaluated using assorted in vitro methods on HaCaT cells. According to the antecedent toxicity screening evaluation, three surfactants were selected (Gelucire 44/14, Labrasol, and Lauroglycol 90) for the formulation. The dissolution rate of PL from the PL-LC systems was evaluated using a Franz diffusion chamber apparatus. The antioxidant properties of the PL-LC systems were evaluated with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and malondialdehyde (MDA) assessments. Our results suggest that these compositions use a nontraditional, rapid-permeation pathway for the delivery of drugs, as the applied penetration enhancers reversibly alter the barrier properties of the outer stratum corneum. These excipients can be safe and highly tolerable thus, they could improve the patient’s experience and promote adherence.