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Tétel Szabadon hozzáférhető Az állami és a magán egészségügy fogyasztói szemmel Magyarországon(2023-02-15) Szigeti, SzilárdThe scope of the study is the opinions of the Hungarian population on publicly and privately owned and financed health services. There is a relationship between the age group of consumers and the type of health service they find acceptable. Primary quantitative research (N=1196) shows that paying out of pocket for a service offered in a state-owned institution is unacceptable. The generation older than 54 years has the least experience with private healthcare, while those aged 36-41 years have the most. Hungarian adults consider private health services to be characterized by short waiting times, fast appointment booking, more human treatment, patient-centredness, and a pleasant environment compared to publicly funded care.Tétel Szabadon hozzáférhető Ápolás és betegellátás alapszakos - gyógytornász szakirányon tanuló hallgatók által ellátott feladatok és a szakmai tanulmányaikhoz kapcsolódó tapasztalatok felmérése a COVID-19 elleni védekezésben(2023-07-15) Besenyei, Blanka; Nagy, Attila Csaba; Balajti, IlonaThe epidemiological situation caused by COVID-19 has led to a need for help in the health care system for students of health sciences. The aim of our research is to assess the experiences of physiotherapy students in Debrecen during the protection against COVID-19. Using a questionnaire method, we wanted to collect information on the extent to which the students were able to use what they had learned and how the practical experience they had gained contributed to their professional development.Tétel Szabadon hozzáférhető A bábterápia és a sématerápia szinergizmusainak ötvözése a pszichoterápiás munkában(2022-07-20) Zsuga, JuditPuppet therapy builds on the educational and developmental effects of puppetry and the healing power of playing. It achieves these beneficial effects thru its special tools, the puppets. Schema therapy, effective in a wide spectrum of psychiatric and psychological disorders has a characteristic tool rooted in dramaturgic plays, so called chair work, that utilizes role playing and change of perspective to gain insight regarding one’s mental processes. This is the context in which potential synergism between schema therapy and puppet therapy could be exploited. The current paper introduces a fairy tale that was written under the premises of schema therapy. It provides a tool for schema mode work and offers a possibility to utilize the therapeutic effect and toolbox of puppet therapy.Tétel Csak a leíró adatok érhetők el Changes in usage of publicly funded metformin medications in Hungary between 2015 and 2019(Health Innovation Review) Biró, KláraTétel Szabadon hozzáférhető Ciklodextrinek szerepe a COVID-19 elleni küzdelemben(2022-07-18) Réti-Nagy, Katalin; Bácskay, Ildikó; Vecsernyés, Miklós; Fenyvesi, FerencSince the emergence of the SARS-CoV-2 virus in late 2019, several therapeutic possibilities have appeared to treat patients who are often in severe condition due to the pathogen. As more information becomes available about the virus, the therapeutic strategies can be more specific. Cyclodextrins are well known molecules in the pharmaceutical industry. Due to their special structure they can be widely used in drug development. One of our main research topic is the application of cyclodextrins, so considering the current pandemic situation, it was relevant for us to summarize the role of cyclodextrin molecules in the therapy of COVID-19 disease. In the course of our literary research, we have found many interesting theories and promising developments.Tétel Szabadon hozzáférhető CK2 inhibitor tartalmú alginát mikrogyöngyök formulálása és vizsgálata különböző segédanyagokkal(2024-05-29) Siposné Fehér, PálmaAbsztrakt A kutatási munka során CK2 inhibitor tartalmú alginát mikrogyöngyöket formuláltunk polimerizációs módszerrel. Egyes készítményekben segédanyagokat használtunk a formulálás során a hatóanyag penetrációjának javítása és a készítményeink stabilitásának növelése érdekében. A hatóanyagot tartalmazó nátrium-alginát keverékhez Transcutol® HP-t adtunk és a kapott eredményeket a segédanyag nélküli mikrogyöngyökkel összehasonlítottuk. A készítményekkel különböző gyógyszerforma vizsgálatokat végeztünk, meghatároztuk a kapszulázási hatékonyságot, a duzzadási viselkedést, enzimatikus stablilitási vizsgálatot és in vitro kioldódási vizsgálatot végeztünk. A formulációk sejtéletképességi vizsgálatához MTT tesztet végeztünk Caco-2 sejtvonalon. Végül a készítmények antioxidáns és gyulladáscsökkentő hatásait értékeltük. A Transcutol® HP alkalmazásával a formulációban javult a CK2-inhibitor készítményben történő stabilitása és permeabilitása.Tétel Csak a leíró adatok érhetők el Combining the synergies of puppet therapy and schematic therapy in psychotherapy(Health Innovation Review) Zsuga, JuditTétel Szabadon hozzáférhető Debreceni iskola-egészségügyi modellprogram(2023-07-15) Papp, CsabaWith the support of the Debrecen County Municipality at Pósa Street No. 1., a nationwide unique school health program has been launched at the Health Development Institute, which establishment was inaugurated on the 11th of October 2019 as part of the Clinical Center of the University of Debrecen. As it is well known, within the framework of the school health care program, operating on the basis of NM decrees 26/1997. (IX. 3.), 51/1997. (XII. 18.) and 33/1998. (VI. 24.), primary and secondary school students participate in mandatory screening tests every two years - during the so-called "indicator" years (the 2nd, 4th, 6th, 8th, 10th and 12th). The goal of DAEFI is to centralise school health objectives and additional examinations as part of a particular model program. After the coronavirus epidemic, the 2021/2022 academic year was the first full term when the screenings defined by the legislation could take place with the coordination of DAEFI, which preventive measures, with parental consent, were supplemented with an EKG examination as well as Prevention Lectures. We are now presenting the experiences of this first year.Tétel Szabadon hozzáférhető Fogyatékossággal élő személyek jogairól szóló egyezmény vonatkozásai a pszichiátriai betegek ellátásával összefüggésben(2023-07-15) Bányai, GáborDignity is considered the basis of human existence, and legislation seeks to ensure this for all people. This principle of equality requires that neither the state, nor society should discriminate between fellow human beings. The prohibition of discrimination therefore reassures the principle of equality legal equality and lists disability among the characteristics to be protected. Consequently, special attention must be paid to the protection of the dignity and rights of persons with disabilities in all areas of life. Following the promulgation of the Convention on the Rights of Persons with Disabilities and the related Optional Protocol the harmonization of Hungarian regulations began based on the new definition of disability. The new definition includes persons living with mental impairment. We will discuss the purpose and effect of the legal instruments created and still being developed as a result of the Convention, as well as the additional necessary measures to create equal opportunities for persons with mental disabilities within health care, focusing specially on psychiatric care.Tétel Szabadon hozzáférhető Formulation and testing of prebiotic capsules(Health Innovation Review) Siposné Fehér, PálmaTétel Szabadon hozzáférhető Formulation of Novel Liquid Crystal (LC) Formulations with Skin-Permeation-Enhancing Abilities of Plantago lanceolata (PL) Extract and Their Assessment on HaCaT Cells(Health Innovation Review) Kósa, Dóra; Pető, Ágota; Fenyvesi, Ferenc; Váradi, Judit; Vecsernyés, Miklós; Gonda, Sándor; Vasas, Gábor; Fehér, Pálma; Bácskay, Ildikó; Ujhelyi, ZoltánTétel Szabadon hozzáférhető A gyógyszerészi gondozás lehetőségei az ortopédiai gyakorlatba(2023-02-15) Karácsonyi, Zoltán; Erdei, TamásClinical pharmacy developed at the end of the 20th century in the United States of America, the undisclosed purpose of which is to expand the role of the pharmacist profession and to optimize patient-specific drug therapy. This change in attitude gave rise to the definition of pharmaceutical care, which gained ground both in the clinic and in public drug supply. While the effects of pharmaceutical care on the health care system can be better examined in the case of public drug supply chains with a larger number of patients, the role of care provided by clinical pharmacists in institutions providing orthopedic care has been little investigated, even though the available studies have yielded positive results regarding the quality and cost-effectiveness of health care.Tétel Szabadon hozzáférhető Hidroxi-propil-béta-ciklodextrin celluláris internalizációjának és lizoszómákra gyakorolt hatásának vizsgálata(2023-07-15) Rusznyák, Ágnes; Réti-Nagy, Katalin; Váradi, Judit; Bácskay, Ildikó; Vecsernyés, Miklós; Fenyvesi, FerencCyclodextrins are widely used excipients to increase water solubility and bioavailability of lipophilic drugs. Our research group previously showed that cyclodextrins are able to enter Caco-2 intestinal epithelial cells by endocytosis, however, the cellular internalization and intracellular effects in the case of different cells have not been investigated yet. In addition, 2-hydroxypropyl-beta-cyclodextrin (HPBCD) is a potential molecule for the treatment of Niemann Pick syndrome type C due to its cholesterol complexing properties. The aim of our work is to investigate and compare the cellular internalization of HPBCD and its effect on lysosomes on Caco-2 intestinal epithelial, HeLa cervical epithelial and hCMEC/D3 brain endothelial cells.Tétel Szabadon hozzáférhető Integratív Diszlexia-terápia(2023-02-15) Schéder, VeronikaThe study presents a reading skills development programme supported by complex movement exercises, which we recommend for re-education of children with dyslexia and/or dysgraphia. The programme is targeted at two age groups: on the one hand, at 2nd, 3rd and 4th graders and on the other hand, the at age group between 10 and 18 years. As yet, our innovative method is unknown in research and its effectiveness is supported by positive practical experience as well as the results of a pilot study.Tétel Szabadon hozzáférhető A kannabidiol és az adenozinerg rendszer kapcsolata(2023-07-15) Viczján, Gábor; Óvári, Ignác; Erdei, Tamás DánielCannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects. The aim of this review is to describe the various effects of CBD, since it seems to have several molecular targets, acting at which CBD can modify several pathological conditions. CBD has anti-inflammatory, anti-cancer, neuroprotective, anticonvulsant, anxiolytic, antipsychotic, antidepressant, antidiabetic and anti-obesity effects, furthermore it can affect the functions of the adenosinergic system as well. Regarding myocardial adenosinergic system, CBD is thought to influence two important targets: the A 1 adenosine receptor and the equilibrative and nitrobenzylthioinosine-sensitive nucleoside transporter (ENT1 or SLC29A1). ENT1 is a main equilibrative adenosine transporter capable of regulating the interstitial level of adenosine, while the A 1 adenosine receptor is a chief protective receptor of the myocardium.Tétel Szabadon hozzáférhető A koronavírus és a renin-angiotenzin rendszer kapcsolata a COVID-19 elleni gyógyszerek fejlesztésének tükrében(2023-02-15) Gesztelyi, RudolfSARS-Co-V of the Coronaviridae family emerged in 2019 in China and soon generated a pandemic. Albeit COVID-19 did not have as high death toll as some earlier pandemics, the severity and course of disease proved to be unpredictable if factors related to general health and case history of patients were considered. Thus COVID-19 due to its potentially fatal outcome and unpredictability demanded protective measures to be taken that were not sustainable in the long run (e.g. quarantining masses of people) during the early course of the pandemic (prior to the availability of vaccination and medications). Nonetheless, the vaccine for COVID-19, albeit showed efficacy, failed to reach the level of protection the former vaccines for other communicable diseases did. Additionally, available pharmaceutical treatmentregimens were not efficacious enough in preventing fatal outcome or long-term complications. These facts underscore the necessity of initiatives that seek future avenues for drug development, with special emphasis being placed on repositioning of medications with well-established use. Upon reviewing available scientific evidence four potential approaches may be identified that if repositioned could be evaluated as anti-COVID-19 agents: 1.) manipulating the a renin-angiotensin system by the use of angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs); 2.) inhibiting the binding between human ACE2 enzyme and SARS-CoV-2 spike protein by N-acetylcysteine, or possibly quercetin; 3.) increasing the activity of ACE2 using ibuprofen; 4.) administration of prebiotics, probiotics or tryptophan to normalize SARS-CoV-2 induced dysbiotic changes of the microbiome.Tétel Szabadon hozzáférhető magyarországi palliatív és hospice ellátás új eleme, a debreceni Hospice-Palliatív Terápiás Osztály(2023-02-15) Porkoláb, Gyöngyi; Dózsa, Csaba LászlóThe hospice-palliative care developing as a bottom-up initiative in Hungary, has gradually integrated into the Hungarian healthcare system, continuously evolving to meet the demographic trends and public health challenges. Ensuring the dignity of patients while providing end-of-life care has become a universally accepted horizontal principle of healthcare. This trend has brought to life the establishment of dedicated palliative-hospice departments throughout the country: overall 96 hospice healthcare providers are operational, utilizing funds from the National Health Insurance Fund, foundations and other sources. The Hospice-Palliative Therapy Unit was opened in 2017 in Debrecen, with 20 chronic beds and 120 hour/day/month ambulatory home-care capacity. Currently the Unit is hosted in the University of Debrecen. The operation of the Hospice-Palliative Therapy Unit is supported by the Debrecen Hospice House Foundation ever since its establishment in 2015. The Fields of Dignity is an initiative widely open for the public that must be highlighted. This initiative brought substantial social innovation with its innovative program elements leading to the understanding and acceptance of hospice-palliative care. In summary it must be articulated that albeit the focus of hospice care is the provision of end-of-life care, it fills a void by raising awareness of the value of life, honesty, mutual respect and caring. Hence the sustainable and continued operation of the hospice-palliative care the regional and national capacity and infrastructure is mandatory alongside the establishment of financing home-based care in agreement with the recommendations of the National Palliative Strategy.Tétel Szabadon hozzáférhető olvasástanítás ortográfiás módszere-bizonyítékok és lehetőségek(2024-05-29) Zsuga, JuditAz olvasás az egyén tanult képessége, ami lehetővé teszi írott szöveg megértését és értelmezését. Az OECD országokban a szövegértés terén mért PISA (Programme for International Student Assessment) pontszámok fokozatos romlása alapján felvethető, hogy az olvasás tanításában szükség lehet új megközelítések kidolgozására, elsősorban a jelenlegi módszerekkel rosszul boldogulók számára. Az olvasástanítás hagyományosan a hang-betű megfeleltetés (silabizálás) elsajátításával kezdődik a betűkön alapuló írásrendszert használó országokban. Magyarországon a továbblépést rendszerint az egyes szótagokat alkotó betűk hangos összeolvastatása jelenti. Az agyműködés sajátosságaira fókuszáló kutatások felvetik az ortográfiás-morfológiai szegmentálásra alapozott módszerek igen eredményesek lehetnek. A továbbiakban bemutatásra kerül egy, a betű-bigram-morféma tagoláson alapuló, jelenleg pilot szakaszban járó, ún. ortográfiás olvasástanítási módszer, ami a jelenleg ismert neurobiológiai alapokra építve az agyi ventrális vizuális feldolgozólánc sajátosságait igyekszik figyelembe venni. A módszer lényege, hogy az olvasástanulás során a teljes szavak összeolvasás során, a betű – bigram (két, az adott nyelvben gyakran egymás mellé kerülő betű) – morféma (a legkisebb, már önálló jelentéssel bíró nyelvi egység) hierarchia szerint halad a tanulás. A gyerekek kezdettől fogva összefüggő magyar szöveget olvasnak hangos olvasással, mely biztosítja, hogy a gyerekek kontextuálisan gazdag környezetben találkozzanak az írott nyelvi elemekkel. Az ortográfiás olvasástanítási módszer jelentőségét a jövőbeli kontrollált vizsgálatok eredményei dönthetik el.Tétel Szabadon hozzáférhető Prebiotikum tartalmú kapszulák formulálása és vizsgálata(2022-07-18) Bácskay, Ildikó; Újhelyi, Zoltán; Pető, Ágota; Kósa, Dóra; Józsa, Liza; Vasas, Gábor; Zsuga, Judit; Siposné Fehér, PálmaPrebiotics are non-digestible food ingredients that reach the colon unchanged, serving as nutrients for bacterial strains that are beneficial to the body and helping them to multiply. The aim of the present experimental work was to formulate a capsule with a prebiotic composition. The capsule composition was formulated from different prebiotics: inulin, galacto-oligosaccharide, pectin. In addition to prebiotics, the product contains zinc citrate. The pharmacopoeia and other dosage form test of the powder mixture and capsules were examined. The average weight of the capsules, the uncompressed and compressed density of the capsule filling, the particle size distribution by sieve analysis and the fluidity of the powder mixture were determined. In addition, the homogeneous distribution of zinc citrate in the powder mixture was investigated using an analytical method. The results of the tests confirmed that the composition is technologically appropriate. The chosen manufacturing technology and sequence of operations ensure a homogeneous distribution of components and the reproducibility.