Development of a new database for the definition of transcription units based on human ChIA-Pet and ChIP-seq data in 3D proximity of CTCF binding domains

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dc.contributor.advisorBarta, Endre
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet
dc.contributor.authorShihab Aldeen, Yanal
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentSzékvölgyi, Lóránt
dc.contributor.opponentdeptDebreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék
dc.date.accessioned2023-06-08T14:00:14Z
dc.date.available2023-06-08T14:00:14Z
dc.date.created2023-04-25
dc.description.abstractChIA-PET data helps understand the proximity of sequences and their positions in a 3D structure, while CHIP-SEQ identifies sequences that specific proteins interact with. By combining both methods, we can identify the relationship between promoter-protein complexes and other nearby sequences. CTCF is a highly conserved protein that plays a crucial role in DNA replication, chromatin architecture, and gene regulation. It mediates long-range chromatin interactions and acts as a barrier component to prevent the transfer of epigenetic markers. Raw ChIA-PET data was evaluated using ChIA-PET TOOLS v3 to identify promoter sequences close to CTCF binding domains, indicating that CTCF and the cohesin ring play a role in promoter activity.
dc.description.correctorLB
dc.description.coursemolekuláris biológia
dc.description.courselangangol
dc.description.coursespecBiokémia-genomika
dc.description.degreeMSc/MA
dc.format.extent40
dc.identifier.urihttps://hdl.handle.net/2437/354877
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectCTCF
dc.subjectRAD21
dc.subjectChIA-PET
dc.subject.dspaceDEENK Témalista::Biológiai tudományok::Molekuláris biológia
dc.titleDevelopment of a new database for the definition of transcription units based on human ChIA-Pet and ChIP-seq data in 3D proximity of CTCF binding domains
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Theses (Faculty of Medicine)