[S]GalR, GalX and AraR co‐regulate ‐galactose and ‐arabinose utilization in

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dc.contributor.authorMeng, Jiali
dc.contributor.authorNémeth, Zoltán
dc.contributor.authorPeng, Mao
dc.contributor.authorFekete, Erzsébet
dc.contributor.authorGarrigues, Sandra
dc.contributor.authorLipzen, Anna
dc.contributor.authorNg, Vivian
dc.contributor.authorSavage, Emily
dc.contributor.authorZhang, Yu
dc.contributor.authorGrigoriev, Igor V.
dc.contributor.authorMäkelä, Miia R.
dc.contributor.authorKaraffa, Levente
dc.contributor.authorde Vries, Ronald P.
dc.contributor.authorNémeth Zoltán (1987-) (egyetemi tanársegéd, okleveles biomérnök)
dc.contributor.authorFekete Erzsébet (1975-) (biotechnológus)
dc.contributor.authorKaraffa Levente (1971-) (mikrobiális élettan és biotechnológia)
dc.contributor.authorKaraffa Levente (1971-) (mikrobiális élettan és biotechnológia)
dc.contributor.submitterdepBiotechnológiai Intézet -- 4401
dc.contributor.submitterdepMetagenomikai Intézet -- 4453
dc.contributor.submitterdepBiomérnöki Tanszék -- 755
dc.contributor.submitterdepTTK
dc.contributor.submitterdepDebreceni Egyetem
dc.date.accessioned2024-03-27T11:46:55Z
dc.date.available2024-03-27T11:46:55Z
dc.date.oa2024-04-02
dc.date.updated2024-03-27T11:46:55Z
dc.description.abstractFilamentous fungi produce a wide variety of enzymes in order to efficiently degrade plant cell wall polysaccharides. The production of these enzymes is controlled by transcriptional regulators, which also control the catabolic pathways that convert the released monosaccharides. Two transcriptional regulators, GalX and GalR, control d-galactose utilization in the model filamentous fungus Aspergillus nidulans, while the arabinanolytic regulator AraR regulates l-arabinose catabolism. d-Galactose and l-arabinose are commonly found together in polysaccharides, such as arabinogalactan, xylan and rhamnogalacturonan I. Therefore, the catabolic pathways that convert d-galactose and l-arabinose are often also likely to be active simultaneously. In this study, we investigated the interaction between GalX, GalR and AraR in d-galactose and l-arabinose catabolism. For this, we generated single, double and triple mutants of the three regulators, and analysed their growth and enzyme and gene expression profiles. Our results clearly demonstrated that GalX, GalR and AraR co-regulate d-galactose catabolism in A. nidulans. GalX has a prominent role on the regulation of genes of d-galactose oxido-reductive pathway, while AraR can compensate for the absence of GalR and/or GalX.
dc.description.correctorSZKM
dc.identifier.citationMicrobial Biotechnology. -15 : 6 (2022), p. 1839-1851. -Microbial Biotechnology. -1751-7915. -1751-7915
dc.identifier.doi10.1111/1751-7915.14025
dc.identifier.issn1751-7915. -
dc.identifier.issn1751-7915
dc.identifier.opachttps://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM119878
dc.identifier.urihttps://hdl.handle.net/2437/367963
dc.identifier.urlhttps://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.14025
dc.languageeng
dc.rights.accessopen access article
dc.rights.ownerSzerző
dc.subject.otheridegen nyelvű folyóiratközlemény külföldi lapban
dc.subject.otherTRANSCRIPTIONAL ACTIVATOR XLNR
dc.subject.otherPRIMARY CARBON METABOLISM
dc.subject.otherD-XYLOSE REDUCTASE
dc.subject.otherCATABOLIC PATHWAY
dc.subject.otherBETA-GALACTOSIDASE
dc.subject.otherMISSING LINK
dc.subject.otherIDENTIFICATION
dc.subject.otherDEHYDROGENASE
dc.subject.otherNIGER
dc.subject.otherEVOLUTION
dc.tenderNKFIA NN128867 -- Egyéb
dc.title[S]GalR, GalX and AraR co‐regulate ‐galactose and ‐arabinose utilization in
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