Association between genetic polymorhisms and external apical root resorption

Abstract

The primary goal of the work presented was to identify an association between genetic predisposition to EARR and the clinically developed condition of EARR. The following link was established based on an analysis of 19 independent studies for various single nucleotide polymorphisms, where some showed a significant impact on the emergence of EARR while others confirmed the lack of any influence. Several single nucleotide polymorphisms must be examined and investigated further to determine their impact on the occurrence and progression of EARR. Mutations in cytokines involved in the root resorption molecular pathway were found to have a significant effect on EARR. The polymorphisms of IL-1B, IRAK-1, IL-6, P2RX7, and VDR had the greatest effect of the polymorphisms presented.