Development of personal nasal protective device and device for formulated nanoparticles

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dc.contributor.advisorUjhelyi, Zoltán
dc.contributor.authorQuoc , Thinh To
dc.contributor.authorvariantQuoc , Thinh To
dc.contributor.departmentGyógyszertudományok doktori iskolahu
dc.contributor.submitterdepGyógyszerésztudományi Kar
dc.date.accessioned2025-05-14T10:54:26Z
dc.date.available2025-05-14T10:54:26Z
dc.date.defended2025-05-29
dc.date.issued2025
dc.description.abstractNasal drug administration has been a key focus of scientific research for decades due to its numerous advantages in targeted drug delivery. Various drug delivery systems and devices are being developed to enhance treatment effectiveness and improve patient comfort. The benefits of intranasal drug delivery are well-established, as the nasal mucosa provides an excellent surface for the rapid and efficient absorption of active compounds. The extensive nasal surface area and high absorption capacity enable certain substances to reach the central nervous system directly, bypassing the blood-brain barrier. Pharmaceutical formulations intended for nasal application are typically solutions or liquid-based dispersions such as emulsions and suspensions. In recent years, the development of nanostructured drug carriers has advanced significantly. Solid-phase heterogeneous dispersion systems represent a novel approach in pharmaceutical technology, facilitating the efficient delivery of a wide variety of active ingredients. Our research aimed to develop a solid drug delivery system that integrates these well-known advantages. By utilizing nanoparticles, we not only leveraged their small size but also optimized the adhesive and penetration-enhancing properties of excipients to improve efficiency. Beyond drug-based nasal treatments, increasing emphasis is being placed on respiratory protection against both infectious and non-infectious environmental hazards. With growing concerns over pollution-related illnesses, there is a heightened interest in personalized protective solutions against various pathogens. The development of innovative protective devices relies not only on medical advancements but also on engineering and technological innovations. One promising approach is the use of customized nasal filters, which can effectively block airborne pollutants and pathogens. These small nasal devices are designed to filter out dust, allergens, and microorganisms from inhaled air. Additionally, personalized nasal filters may contribute to immune system support by adapting protection to an individual's genetic and immunological profile. During development, not only efficiency but also user preferences are prioritized, as comfort and ease of use are crucial for widespread adoption. Industrial research increasingly seeks to integrate technological advancements into practical, user-friendly solutions for everyday life. Consequently, customized nasal filters present an innovative and promising method for safeguarding against air pollution and harmful microbes. Through continuous technological research and development, these devices could have a lasting impact on both human health and environmental protection. Ongoing studies and novel solutions give hope that in the future, we will be able to protect our health in even more advanced and effective ways, despite ever-evolving environmental challenges.
dc.format.extent96
dc.identifier.urihttps://hdl.handle.net/2437/389910
dc.language.isoen
dc.subjectnasal formulations, nanoparticles, penetration enhancers, nasal protective device
dc.subject.disciplineGyógyszertudományokhu
dc.subject.sciencefieldOrvostudományokhu
dc.titleDevelopment of personal nasal protective device and device for formulated nanoparticles
dc.title.translatedSzemélyre szabott nazális filter és gyógyszeres nanorészecskék adagolására szolgáló eszköz fejlesztése
dc.typePhD, doktori értekezéshu
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