Comparative efficacy of statins and non-statin treatment of hyperlipidemia
| dc.contributor.advisor | Pórszász, Róbert | |
| dc.contributor.advisordept | Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet | |
| dc.contributor.author | Kim, Yu Rim | |
| dc.contributor.department | DE--Általános Orvostudományi Kar | |
| dc.contributor.opponent | Szentmiklósi, József | |
| dc.contributor.opponent | Halasi, Barbara Dóra | |
| dc.contributor.opponentdept | Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet | |
| dc.contributor.opponentdept | Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet | |
| dc.date.accessioned | 2025-10-16T12:42:44Z | |
| dc.date.available | 2025-10-16T12:42:44Z | |
| dc.date.created | 2025-08-31 | |
| dc.description.abstract | Hyperlipidemia, particularly elevated LDL-C, is a key modifiable driver of atherosclerotic cardiovascular disease, making lipid-lowering therapy central to prevention. Statins remain the first-line treatment, backed by strong evidence of LDL-C reduction and decreased cardiovascular morbidity, but many patients either fail to achieve guideline targets or cannot tolerate them. This thesis compares statin monotherapy, statin-plus-non-statin combinations, and non-statin monotherapy, evaluating agents such as ezetimibe, PCSK9 inhibitors, bempedoic acid, and inclisiran. Evidence shows that PCSK9 inhibitors and inclisiran achieve the largest LDL-C reductions when added to statins, while ezetimibe and bempedoic acid provide moderate but meaningful benefits, and non-statins alone serve as important alternatives for statin-intolerant patients. The analysis concludes that personalized, risk-based strategies balancing efficacy, safety, cost, and adherence are essential to optimize lipid management and reduce long-term cardiovascular risk. | |
| dc.description.course | általános orvos | |
| dc.description.courselang | angol | |
| dc.description.degree | egységes, osztatlan | |
| dc.format.extent | 39 | |
| dc.identifier.uri | https://hdl.handle.net/2437/397963 | |
| dc.language.iso | en | |
| dc.rights.info | Hozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében. | |
| dc.subject | Hyperlipidemia | |
| dc.subject.dspace | Medicine | |
| dc.title | Comparative efficacy of statins and non-statin treatment of hyperlipidemia |
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