Theses (Faculty of Pharmacy)

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https://hdl.handle.net/2437/193441

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Theses (Faculty of Pharmacy) Tárgyszó szerinti böngészés "aging"

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    Selected key aspects of the cutaneous mitochondrial biology - a brief overview
    Badmaev, Dzhangar; Oláh, Attila; Department of Physiology; DE--Gyógyszerésztudományi Kar; Törőcsik, Dániel; Szőllősi, Attila; Debreceni Egyetem::Általános Orvostudományi Kar; Debreceni Egyetem::Általános Orvostudományi Kar; Department of Immunology; Department of Dermatology
    The mitochondrion has long been recognized as a chemical powerplant, hosting a variety of biosynthetic and regulatory pathways within its membrane-bound compartment enclosed around the functional matrix. Evidence and insight into the aspects of mitochondrial biology accrued over the years have focused mostly on the highly energy-dependent tissues such as skeletal muscles, neurons, brown, beige, and white adipocytes, among many others. However, it is now becoming more and more obvious that derangements of mitochondrial function may play a role in the development of certain skin pathologies as well. Indeed, recent evidence has provided a more immanent role of mitochondria in the maintenance of cutaneous physiology and homeostasis, which is briefly reviewed in the current thesis. In addition, the following thesis will focus on the link between the genetic lesions within the mitochondrial DNA (mtDNA) and photo-aging as well as malignant transformation. The thesis will conclude with the discussion of potential therapeutic targets inherent to mitochondrial physiology, which may present a basis for the development of therapeutic molecules for potential employment in the field of clinical dermatology. A better understanding of mitochondrial function in healthy and diseased skin promises to highlight a bevy of potential biopharmaceutical compounds, having the potential to slow down or even reverse the progression of the pathogenesis of certain disorders of the skin. The author of this thesis attempts to give a brief, but well-rounded discussion of the role of mitochondria at the operational helm of the selected major aspect of cutaneous physiology (e.g., epidermal keratinocyte differentiation, folliculogenesis, aging and oxidative stress, skin pigmentation) along with a sound mechanistic rationale for the elaboration of pharmacological interventions for skin diseases targeting primarily the cutaneous mitochondria.