Theses (Faculty of Pharmacy)
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Theses collection of the Faculty of Pharmacy. The collection was started in 2015.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
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Tétel Korlátozottan hozzáférhető The role of Oxidative Stress and Antioxidants treatment in Diabetes MellitusHoang Long, Truong; Bak, István; Debreceni Egyetem::Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Debreceni Egyetem::Gyógyszerésztudományi KarThis thesis aims are to provide the basic theoretical background about the pathophysiology of diabetes, antioxidants physiology, and the correlation between diabetes and oxidative stress. Based on this knowledge, results from experimental and clinical studies will be discussed and investigated to answer the question of whether antioxidants were effective in the treatment of diabetes and its complication.Tétel Korlátozottan hozzáférhető Overview of the Genetic Background Influencing the Pharmacokinetics and Pharmacodynamics of StatinsWu, Shuyi; Keserű, Szilvia Judit; Debreceni Egyetem::Általános Orvostudományi Kar::Humángenetikai Tanszék; DE--Gyógyszerésztudományi Kar; Juhász, Béla; Bacskay, Ildikó; Debreceni Egyetem::Általános Orvostudományi KarStatins are regular and universal medications for preventing cardiovascular disease and hyperlipidemia. Despite their effectiveness, statin response varies significantly between individuals, which can be attributable to a number of genetic factors and personal medication habits. This thesis aims to review the genetic factors affecting the pharmacodynamics and pharmacokinetics of statins.Tétel Korlátozottan hozzáférhető Hv1 novel peptide inhibitor extracted from tarantula venomRahpeymaei, Ali; Papp, Ferenc; Általános Orvostudományi Kar::Biofizikai és Sejtbiológiai Intézet::Biofizikai Tanszék; DE--Gyógyszerésztudományi Kar; Eszter Feher, Palma; Naseem Muhammad, Umair; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; Általános Orvostudományi Kar::Biofizikai és Sejtbiológiai Intézet::Biofizikai TanszékThis thesis investigates the interaction between GsAF-I, a peptide from the venom of the tarantula Grammostola rosea, and human voltage-gated proton (Hv1) channels, critical in pH regulation and cellular signaling. Utilizing patch clamp techniques on genetically modified Chinese Hamster Ovary cells expressing human Hv1, the study revealed that GsAF-I significantly stabilizes the closed state of these channels, thereby delaying their opening and hastening their closure, with these effects being notably voltage-dependent. The fast onset and reversibility of GsAF-I's actions suggest its potential for therapeutic use, particularly in treating conditions associated with abnormal proton flux, such as cancer and inflammation. These findings underscore the therapeutic promise of tarantula-derived peptides in modulating ion channel activity and contributing to new treatments for diseases involving disrupted proton flux.Tétel Korlátozottan hozzáférhető The preventive and therapeutic effects of molecular HydrogenNguyen, Mai My Hong; Bak, István; Department of Bioanalytical Chemistry; DE--Gyógyszerésztudományi Kar; Lekli, István; Debreceni Egyetem::Gyógyszerésztudományi KarHydrogen gas, which was previously considered to be physiologically inert in mammalian cells, is now considered as a novel selective antioxidant with potentially therapeutic applications and minor adverse effects. Its selectivity presents through its mild effect that is enough neither to disturb metabolic redox reactions nor to affect ROS, which function in cell signaling. This thesis reviewed the development of hydrogen in therapy, which includes its characteristic, production, possible underlying mechanisms and therapeutic applications. However, the primary targets of molecular hydrogen still remain elusive. Thus, further research is needed to determine the underlying mechanisms of therapeutic effects, antioxidant, anti-inflammatory and apoptotic ways, which will certainly advance the important molecule in clinical applications.Tétel Korlátozottan hozzáférhető Relationship between sunshine duration and antidepressant consumption in three Northern countries– a pharmacoepidemiologic approachTran, Anh Tuan; Horváth, László; Department of Pharmaceutical Surveillance and Economics; DE--Gyógyszerésztudományi Kar; Debreceni Egyetem::Gyógyszerésztudományi KarDepression is a common mental health problem that involves a low mood and a loss of interest in activities. In persons with a chronic medical disease, depression often makes the management of chronic illness more difficult. Recently, vitamin D has been reported in the scientific and lay press as an important factor that may have significant health benefits in the prevention and treatment of many chronic illnesses, such as depression. Sun exposure is known as the most important source of vitamin D. Unfortunately, people who live in northern regions can be difficult to obtain all vitamin D. With a pharmacoepidemiological approach, this study shows the relationship between sunshine duration and antidepressant consumption.Tétel Korlátozottan hozzáférhető Dietary SupplementsSayegh, Areen; Lekli, István; Debreceni Egyetem::Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi KarDietary supplements are widely spread on the market and are used by individuals of various population groups. Yet their safety remains questionable and their use is accompanied with risks based on the currently available research data. Stricter regulations of their market must be implemented by competent authorities to protect consumers.Tétel Korlátozottan hozzáférhető The impact of pharmaceutical care intervention type 2 diabetes.Okocha Rufus, Ogechi Chinenye; Bácskay, Ildikó; Pharmaceutical care; DE--Gyógyszerésztudományi Kar; Lekli, István; Debreceni Egyetem::Gyógyszerésztudományi KarDiabetes is a growing epidemic that affects persons of all ages and races. The disease reduces both a person's quality of life and life expectancy and imposes a large economic burden on the health care system and on families. Diabetes has claimed so many lives and caused a lot of disabilities in affected individuals. It is an issue that must be concretely addressed to prevent further cases from occurring. This thesis aims at providing relevant information about diabetes, its prevention, treatment and management by focusing on type 2 diabetes and the pharmaceutical care aspects of its management.Tétel Korlátozottan hozzáférhető original and generic drugsTran, Tuan Huy; Horváth, László; Debreceni Egyetem; DE--Gyógyszerésztudományi Kar; Mihaly, Herczeggeneric drug plays an important role in the modern healthcare system. as more and more patents expire, the generic portion of the pharmaceutical market is predicted to continue to enlarge sales. Generic drugs provide patients with safe and effective therapeutic choices.Tétel Korlátozottan hozzáférhető Filtration Theoretical bases of filtration Types of instruments for filtrationKocak, Mert; Fehér, Pálma; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Bácskay, Ildikó; Debreceni Egyetem::Gyógyszerésztudományi KarFiltration is basically determine to seperate solid particles from liquid particles.Firstly,it is very important in our life,because the world needs to water through the process of filtration produces safetly drinking water.There are many types of process for filtration in our life.It is mentioned about objective filtration,types of filtration,method filtration,mechanism filtration,theoretical filtration,application of filtration,filter media,filter aid and types of equipments.We usually use the process of filtration in pharmaceutical laboratory,chemical industry and pharmaceutical technology.Tétel Korlátozottan hozzáférhető Robinia Pseudoacacia ( Black Locust) creamNguyen, Thien Huy; Fehér, Pálma; Pharmaceutical Technology; Debreceni Egyetem::Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Lekli, Istvan; Ildikó, Bácskay; Debreceni Egyetem::Gyógyszerésztudományi KarRobinia pseudoacacia (Black locust) is ideal for making topical therapy cream for some skin treatments because it is also considered to include treatment of burns and wounds, antispasmodic, aromatic diuretic and laxatives, gentle moisturizer which is suitable for normal types of skin.Tétel Korlátozottan hozzáférhető Pharmaceutical Description Of Liquid CrystalsAbdollahzadeh, Aysen; Ujhelyi, Zoltán; Debreceni Egyetem::Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Lekli, István; Bácskay, Ildikó; Debreceni Egyetem::Gyógyszerésztudományi Karnowadays much interest has been focused on lipid based formulations,with particular emphasis on semi solid liquid crystals as a possible drug delivery system to improve the bioavailibility of poorly soluble drugs.the aim of this pharmD thesis work was to demonstrate this novel dosage forms from pharmaceutical stand point.the theoretical background of lipid API carriers had been described according to the relevant literature.formulation techniques had been presented according to the guideline of Gattefosse chemical company suggesstions.in addition to a detailed look at the technical aspects of liquid crystal formulation.this collection of theoretical and technical information and instruction might ensure useful data for pharmacon loaded liquid crystal formulation by suggesting different lipid compositions to reach better bioavailibility and compliance.Tétel Korlátozottan hozzáférhető LE-127/2, a new cannabigerol derivative mediated autophagy in different human melanoma cell linesParvaneh, Nasim; Szabó, Erzsébet; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Tósaki, Ágnes; Szabó, Zsuzsanna; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; Gyógyszerésztudományi Kar::Biofarmácia Tanszékmelanoma, a rapidly increasing type of skin cancer arising from melanocytes, poses a significant global health threat due to its aggressive nature and high mortality rates. Compounds from Cannabis sativa have shown promise in inhibiting melanoma cell growth and inducing cell death. Non-psychoactive cannabinoids like cannabigerol (CBG) have been investigated for their anti-tumor effects, with some success. This study focused on a new CBG derivative, LE-127/2, comparing its effects on melanoma cell growth to the established drug vemurafenib. Additionally, the study explored how LE-127/2 influences autophagy-related proteins in melanoma cells, suggesting that LE-127/2-induced autophagy may inhibit cell proliferation and trigger cell death in melanoma cells.Tétel Korlátozottan hozzáférhető Formulation and evaluation of diclofenac containing microcapsulesJokartangkarami, Mohammadreza; Jozsa, Liza; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Fesus, Adina; Nemes, DanielFormulation of diclofenac-containing microcapsules involves the encapsulation of diclofenac within a protective shell, typically made of biocompatible polymers, to enhance its stability and controlled release characteristics. The process often includes techniques such as emulsion solvent evaporation or interfacial polymerization to achieve uniform microcapsule size and drug distribution. Evaluation of these microcapsules encompasses various parameters including morphology, drug loading efficiency, encapsulation efficiency, in vitro drug release kinetics, and stability under different storage conditions. The performance of diclofenac microcapsules is crucially assessed for their potential therapeutic efficacy, bioavailability enhancement, and minimization of adverse effects, contributing to their applicability in pharmaceutical formulations for targeted and sustained drug delivery.Tétel Korlátozottan hozzáférhető Importance of 3D printing technique in the pharmaceutical technologyBahat, Yusuf Yilma; Bácskay, Ildikó; Pharmaceutical Technology; DE--Gyógyszerésztudományi Kar; Bak, István; Debreceni Egyetem::Gyógyszerésztudományi KarThis thesis contains information about 3D printing.Shows that it can be used in pharmaceutical drug industry.More specifically solid dosage forms.Shows advantages of this new technique and why its a valid form of production.Tétel Korlátozottan hozzáférhető Effect of a LE-127/2, a new CBG derivative, on apoptosis of melanoma cell linesJoby, Sneha; Szabó , Erzsébet; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Szabó, Zsuzsanna; Tósaki, Ágnes; Gyógyszerésztudományi Kar; Klinikai KözpontThe aim of the thesis is to find the effect of cannabinoid derivative LE-127/2 on cell proliferation and apoptosis of human melanoma cells compared to their mother CBG. According to the experimental research, it is very remarkable that LE-127/2 has less cytotoxic effect to HaCaT cells than its mother CBG. The fact that the new CBG derivative has low cytotoxicity to healthy cells could be a potential drug candidate with possibly lower side effects, so that it could be tolerated by patients in the longer term. In summary, we can also conclude that treatment with LE-127/2 leads to apoptosis, with some apoptotic proteins being activated while others do not change significantly.Tétel Korlátozottan hozzáférhető Consideration of nasal dosage formGhaedi, Zahra; Újhelyi, Zoltán; Debreceni Egyetem::Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Bak, Istvan; Debreceni Egyetem::Gyógyszerésztudományi KarThe nasal drug delivery system are incredibly versatile and although the number of potential pharmacons to be employed are quite limited . Nasal drug delivery are incredibly easy to use and also do not intimidate the patient which has a beneficial effect on overall patient complianceTétel Korlátozottan hozzáférhető Technological aspects of wound healingTijani, Oluwafayokemi Moyosola; Váradi, Judit; Debreceni Egyetem::Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Fehér, Pálma; Vasas, Gábor; Debreceni Egyetem::Gyógyszerésztudományi Kar; Debreceni Egyetem::Természettudományi és Technológiai KarThere are different kinds of wounds. The treatment of wounds is almost as urgent as treating a heart attack because life-threatening complications may occur if a wound is not treated properly. In this course-work, I was able to shed some light on different herbs with wound healing properties. Many of these herbs have multiple effects. They were used many years ago before the development of advanced medicine. In fact, some of them are still in use today in developing countries.Tétel Korlátozottan hozzáférhető Degenerative disorders and their treatment in central nervous systemBagheri, Sahand; TOSAKI, ARPAD; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Fenyvesi, ferenc; szabo, zsuzsanna; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; Debreceni Egyetem::Gyógyszerésztudományi Kar::Biofarmácia TanszékNeurodegenerative diseases (ND) such as alzheimer’s disease (AD), parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), huntington’s disease (HD), and multiple sclerosis (MS). All of these diseases have shared the same features. There are no effective therapies for them at the moment, and we can only alleviate the symptoms, which could vary from impairment of cognitive functions, memory, and movement functions. These neuropathological disorders can be diagnosed through the MRI and also PET scan, in each case, we can see the accumulation of abnormal proteins in the patient's CNS, This accumulation becomes toxic (oxidative stress and radicals) and causes irreversible degeneration of neurons.Tétel Korlátozottan hozzáférhető Fájdalomcsillapítás életünk soránMarkó, Nikolett; Lekli, István; Debreceni Egyetem::Gyógyszerésztudományi Kar, Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi KarBemutatom, hogy mi a fájdalom, milyen gyógyszeres fájdalomcsillapítási lehetőségek léteznek. Részletesen jellemzem az NSAID kategóriát, majd ezek alkalmazását bemutatom a terhességtől kezdve az időskorig. A kérdőív egyes részein a mellékelt kérdőív kiértékelése is megtalálható.Tétel Korlátozottan hozzáférhető Ischemic Heart DiseaseMotiei, Mojtaba; Lekli, István; Gyöngyösi, Alexandra; Tósaki, Árpád; DE--Gyógyszerésztudományi KarIschemic Heart Disease.