Theses (Faculty of Pharmacy)
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Tétel Korlátozottan hozzáférhető Advanced siRNA delivery systemKoohestanu, Sina; Fenyvesi, Ferenc; DE--Gyógyszerésztudományi Karsmall interfering RNA which down regulate gene expression guided by sequence complementarity , can be used therapeutically to block the synthesis of disease causing proteins.siRNA play an essential role in treatment of cancer.the basic mechanism is the RNA interference.Tétel Korlátozottan hozzáférhető Alternative treatments for menopause symptomsLeiderman, Anat; Bácskay, Ildikó; Debreceni Egyetem::Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Halmos, Gábor; Fehér, Pálma; Debreceni Egyetem::Gyógyszerésztudományi Kar; Debreceni Egyetem::Gyógyszerésztudományi KarIn my thesis i chose to summarize the different alternative treatments for managing menopause available for women today. It is very important to give information not just about conventional treatments which are important in severe cases but also give other options to women with mild to moderate symptoms .Tétel Korlátozottan hozzáférhető ANTIBIOTIC RESISTANCE IN THE MEMBER STATES OF THE EUROPEAN UNIONUzoh, Anthony; Laszlo, Pal; Department of Public Health and Epidemiology; DE--Gyógyszerésztudományi Kar; Nagy, Atilla; Kovacs, NoraMicrobes resistant to antibiotics were responsible for 700,000 deaths worldwide in 2016. Each year, more than 670,000 infections occur due to bacteria resistant to antibiotics in the European Union and approximately 33 000 people die as a direct consequence of these infections. Without taking action, antibiotic resistance (ABR) will lead to 10 million deaths globally and 390,000 deaths in Europe by 2050. The aim of this thesis to show the trends of ABR bacteria in the EU between 2010 and 2020. In my thesis, I used the Surveillance Atlas of Infectious Diseases by European Centre for Disease Control (ECDC)Tétel Korlátozottan hozzáférhető Antibiotics delay regrowth human stem cellsKarparvar, Amir; Szemen-Nagy, Gábor; DE--Gyógyszerésztudományi Kar; Tósaki, Árpád; Debreceni Egyetem::Gyógyszerésztudományi KarSome drugs that can have harmful effects for stem cellsTétel Korlátozottan hozzáférhető Antidepressants and anxiolytic drugsAkbari, Ramtin; Lekli, István; DE--Gyógyszerésztudományi KarTo determine different classes/types of antidepressants and anxiolytic drugs of pharmacological relevance. To review side effects of antidepressants and anxiolytic drugs. To identify the etiology of depression and anxiety.Tétel Korlátozottan hozzáférhető ANTIVIRAL ACTIVITY SCREENING IN NOSTOC (CYANOBACTERIA) SPECIES.Gilbert-Nwadike, Leonie Chinonye; Milan, Riba; Vasas, Gabor; Természettudományi és Technológiai Kar; DE--Gyógyszerésztudományi Kar; Zsolt , Szűcs; István , Bácsi; Természettudományi és Technológiai KarA study at the University of Debrecen investigated the impact of Nostoc strains on T4 phage infection in E. coli, revealing fractions with potential inhibitory effects. Phages, a crucial component of prokaryotic life, have been extensively studied since their discovery in 1915. Phages exhibit specificity towards bacterial strains, potentially offering targeted treatments with fewer side effects compared to antibiotics. Cyanobacteria produce diverse cyanometabolites with health benefits, including antiviral properties. The potential for targeted gene delivery via phages and therapeutic applications of cyanometabolites against viral infections highlights the significance of ongoing research.Tétel Korlátozottan hozzáférhető Aspects of risk management in healthcare during COVID-19Komissarova, Veronika; Tóth, Béla; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszerügyi Szervezési és Management Tanszék; DE--Gyógyszerésztudományi Kar; Horváth, László; Vecsernyés, Miklós; Debreceni Egyetem::Gyógyszerésztudományi Kar; Debreceni Egyetem::Gyógyszerésztudományi KarSince the beginning of the pandemic in 2020, the control over the spreading of COVID-19 was performed by: implementing lockdown measures, which were supposed to limit impersonal contacts; free testing policies, which allowed early identification and isolation of patients even with minor symptoms; obligatory usage of personal protective equipment; obeying social distancing and curfews. Being impressive for their scale, these interventions inevitably led to global economic recession with long-term consequences we are yet to discover. Thereby, a balanced response leading to the best outcome with minimal economic consequences is an important research goal. This work outlines some aspects of risk management and issue management strategies and reviews available outcomes of the pandemic in a number of countries.Tétel Korlátozottan hozzáférhető Assessing the Impact of Transcutaneous Carbon Dioxide Therapy in Patients with Chronic Diseases and Concurrent Medications: A Comprehensive EvaluationNguyen, Thi Hong Ngoc; Tóth, Béla Ernő; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Bak, István; Váradi, Judit; Gyógyszerésztudományi KarMofetta therapy demonstrates potential as an effective approach for enhancing mobility, reducing dependency, uplifting mood, and augmenting quality of life. Moreover, recognizing Mofetta therapy as part of an integrative treatment plan rather than a standalone intervention is crucial. Despite existing limitations, Mofetta therapy holds promise for patients with musculoskeletal, joint, connective tissue, or circulatory disorders due to its efficacy. This dissertation aims to present the outcomes of Mofetta therapy intervention in 168 patients hospitalized with underlying diseases during 2021-2022, focusing on a comprehensive assessment encompassing physical and quality of life aspects. The study involved assessing various parameters before and after Mofetta therapy, including the 6-minute walk test (6MW), Timed Up and Go (TUG) test, Borg rating of perceived exertion, short form 36 health survey (SF-36), EuroQol 5 Dimensions 5 level version (EQ-5D-5L), EuroQol Visual Analog Scale (EQ-VAS), Functional Independence Measure (FIM), and Barthel Index.Tétel Korlátozottan hozzáférhető Asthma and Anti-Asthma agentsDiyaolu, Oluwagbemisola Osa; Istvan, Lekli; Department of pharmacology; DE--Gyógyszerésztudományi Kar; Fehér, Pálma; Gyöngyösi, AlexandraIt is about the definition of asthma as well as the factors that cause or trigger asthma, its effect globally as well as the management and pharmacotherapy of asthma which also addresses their mode of action. It generally talks about all the things that relate to and helps understand asthma better.Tétel Korlátozottan hozzáférhető asthma and anti-asthmatic agentssherkat, fatemeh; tosaki, arpad; DE--Gyógyszerésztudományi Kar; juhasz, bela; horneth, laszloasthma is chronic inflammation of airway which causes shortness of breath, repeated coughing and wheezing. The treatment is bronchodilator, mast cell stabilizer, corticosteroid, anti IgE.Tétel Korlátozottan hozzáférhető Bases and Excipients used for Cosmetical Formulations and Their Biocompatibility QuestionsJinadu, Ololade Aishat; Fenyvesi, Ferenc; Debreceni Egyetem::Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Váradi, Judit; Csávás, Magdolna; Debreceni Egyetem::Gyógyszerésztudományi KarThe skin is an essential factor in the application of cosmetics. The layers of the skin that form a protective barrier accomplishes a lot of vital roles, which helps with the effect of the external factors such as to protect and preserve the internal body temperature. Cosmetics has been an important factor in our everyday life, whether intentionally or non-intentionally because any product used to beautify, soothe or improve an appearance is considered cosmetics.Tétel Korlátozottan hozzáférhető Benefits of Sodium Alginate Beads As Controlled-Release Drug Delivery SystemTran, Minh Tuan; Ujhelyi, Zoltán; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Váradi, Judit; Fésüs, Adina; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszerhatástani TanszékStudy the advantages of new micro drug delivery systems by microencapsulation technique, specifically, Sodium alginate polymerization as a controlled release drug delivery system over the traditional oral formulationsTétel Korlátozottan hozzáférhető BGP-15 containing Solid-lipid micro- and nanoparticles: Development and CharacterisationNguyen, Minh Huy; Vasvári , Gábor; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi KarSolid-lipid nanoparticles are tiny, spherical carriers composed of a hydrophobic core and an aqueous phase. BGP-15 is a nicotinic amidoxime derivative developed by Hungarian researchers. It is a potential antidiabetic drug candidate with cardio-, neuro-, nephro-, and photoprotective properties. During the experiment, the aim was to formulate a suitable solid-lipid micro- and nanoparticle that contains BGP-15 for controlled delivery to the site of action. Furthermore, this study was designed to evaluate the SLNs prepared by two different techniques: High shear homogenisation and Ultrasonication in terms of drug loading and entrapment efficacy, size distribution and polydispersity index.Tétel Korlátozottan hozzáférhető Botany of Haloxylon salicornicum A Desert Medicinal PlantAlhawsawi, Swmayah; Borbély, György; Debreceni Egyetem::Természettudományi és Technológiai Kar; DE--Gyógyszerésztudományi Kar; Bacskay, Ildikó; Ujhelyi, Zoltán; Debreceni Egyetem::Gyógyszerésztudományi KarThe objectives of this study were to characterize the anatomy and taxonomy of Haloxylon salicornicum and show the biochemical nature of CO2 fixation pathway of the plant in question. We also addressed the possible pharmacognosical aspects of H. slicornicum including the antimicrobial activity of H. salicornicum extracts on bacterial and fungal growth. The further aim is to elucidate the ecological role(s) of H. salicornicum in the deserts and the possible use in agriculture.Tétel Korlátozottan hozzáférhető Challenges and Perspective in Glucose MonitoringMovaghati Moghadam, Arianaz; Ujhely, Zoltán; DE--Gyógyszerésztudományi Kar; Sinka, Dávid; Sipos, ÉvaGlucose monitoring methods can be invasive and non invasive As an invasive method example can ,mention glucometer which approach to blood glucose monitoring that pricking finger and provide result regarding an individual blood glucose level which is fast and most accurate method. As an non invasive method example can mention electrochemical method;but this technologies are yet to make significant advancements.Tétel Korlátozottan hozzáférhető Characterization of chimeric antigen receptor (CAR) Modified T Cells specific for P97 and HMW-MAA human melanomaPham, Huynh Thuy An; Szöőr, Árpád; BIOPHYSICS AND CELL BIOLOGY; DE--Gyógyszerésztudományi KarAnti-p97 and HMW-MAA CAR T cells recognized Melur target cells in vitro. P97 CAR induced faster activation and better cytokine production of T cells, even though the HMW-MAA antigen is expressed to a similar extent on the target tumor cells and the HMW-MAA CAR is known to bind to its target with similar affinity as the p97 does. We hypothesize that a difference in the surface mobility of various melanoma associated antigens might have an impact on CAR T cell activation.Tétel Korlátozottan hozzáférhető Clinical management of acute myocardial infarction from pharmacological point of viewMohammadi, Hamidreza; Tósaki, Árpád; DE--Gyógyszerésztudományi Kar; Halmos, Gabor; Borbás, AnikóMyocardial infarction is a major cause of morbidity and mortality in everyday life, especially in developing countries. It may be defined from various such points of view as clinical image, electrocardiogram results, biochemical markers, and background pathology. Myocardial infarction is a fatal condition resulting from lack of oxygen delivery to cardiac muscle cell leading necrosis of myocardium. The morbidity and mortality of MI is directly related to the severity of the illness, where it can be diagnosed and evaluated based on clinical assessment, electrocardiogram, biochemical examinations, invasive and non-invasive imaging. With rise of the ST segment in electrocardiography or without ST-segment elevation, it is a medical emergency, and the patients need to be transferred to hospital where they can be managed by effective myocardial reperfusion either by thrombolytic agents or percutaneous intervention that will aid to improve the prognosis.Tétel Korlátozottan hozzáférhető Comparative test of different antimicrobial preservatives for external pharmaceutical formulationsBoustanchi, Ali; Nemes, Dániel; DE--Gyógyszerésztudományi KarThis study explores the efficacy of antimicrobial preservatives in topical gels, following European Pharmacopoeia guidelines and Hungarian national formulary standards. Results indicate that benzoic and sorbic acid salts exhibit significant antimicrobial activity, making them promising alternatives to parabens. However, zinc gluconate and ethanolic solutions of methyl paraben showed limited efficacy. Surprisingly, the choice of gelling agent did not significantly affect the effectiveness of the tested materials. Overall, the study contributes to enhancing the safety and efficacy of external pharmaceutical formulations by addressing concerns about preservative toxicity and ensuring microbial stability throughout product shelf life.Tétel Korlátozottan hozzáférhető Comparative test of different antimicrobial preservatives for external pharmaceutical formulationsBoustanchi, Ali; Nemes, Daniel; DE--Gyógyszerésztudományi KarThis thesis delves into the crucial role of antimicrobial preservatives in external pharmaceutical formulations, with a specific focus on their efficacy in topical gels. Through adherence to European Pharmacopoeia guidelines and referencing the Hungarian national formulary, Formulae Normales VIII, various preservatives were rigorously evaluated. Findings reveal that benzoic and sorbic acid salts exhibit notable antimicrobial activity, suggesting their viability over traditional options like methyl paraben. Importantly, this study underscores the significance of selecting appropriate preservatives regardless of the gelling agent, aiming to enhance both safety and efficacy while addressing concerns regarding preservative toxicity and ensuring microbial stability throughout product shelf life.Tétel Korlátozottan hozzáférhető Comparison of different methods in sampling and sample preparation of Chlorpromazine from biological matrixNguyen, Thai Minh Hoang Jr; Nguyen, Thai Minh Hoang Jr; Bak, István Jr; Bak, István Jr; Debreceni Egyetem::Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi Kar; Kiss, Attila Jr; Kiss, Attila Jr; Debreceni Egyetem::Természettudományi és Technológiai Kar::Kémiai Intézet; Debreceni Egyetem::Természettudományi és Technológiai Kar::Kémiai IntézetIn this thesis, the efficiency and operational aspects of 2 extraction methods, microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME), were compared by their performance in quantifying chlorpromazine (CPZ) concentration of rat plasma samples. The extracts were then be analyzed by GCMS. Unfortunately, the GCMS instrument had a technical dysfunction before the final experiments could be performed. Despite that, it is shown that although it required a more complicated method development, SPME has better accuracy when analyzing the CPZ content of the samples than MEPS. However, the study still needs further investigation for strengthening the findings