Theses (Faculty of Medicine)
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Theses collection of the Faculty of Medicine. The collection was started in 2014.
At the University of Debrecen, in accordance with the 2022 amendment to the 2011 Higher Education Act, student theses are only accessible from devices connected to the University's Eduroam WiFi network or from a university IP address.
“The thesis or diploma work of a student who has successfully passed the final examination shall be stored in full in the academic system of the higher education institution, and a record shall be maintained thereof. The stored theses and diploma works – with the exception of parts classified as confidential in accordance with the relevant legislation – must be made accessible and searchable without restriction through the academic system.” Further info on the National Higher Education Act in Hungarian: Felsőokt. tv. (új) - 2011. évi CCIV. törvény a nemzeti felsőoktatásról - Hatályos Jogszabályok Gyűjteménye.
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Theses (Faculty of Medicine) Cím szerinti böngészés
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Tétel Korlátozottan hozzáférhető A Modern Pharmacological Approach to AnticoagulationGammoh, Nasser; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Megyeri, Attila; Halasi, Barbara Dóra; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Általános Orvostudományi Kar::Igazságügyi Orvostani IntézetThis literature review examines the evolution, mechanisms, and clinical applications of anticoagulant therapies. It is focused on comparing traditional agents like warfarin and heparins with modern direct oral anticoagulants (DOACs). The review first explains the coagulation cascade and its physiological regulation. The pharmacology of anticoagulant drugs is also examined to explain how these drugs target different points in the coagulation process. The paper also describes the clinical indications of anticoagulation such as the prevention and treatment of thromboembolic events like deep vein thrombosis, pulmonary embolism, atrial fibrillation-related stroke, and acute coronary syndromes. Warfarin and unfractionated heparin (UFH) have historically been the foundation of anticoagulant therapy for decades, with warfarin being essential in certain contexts due to its efficacy. Heparins are effective but limited by risks like heparin-induced thrombocytopenia and administration challenges. The introduction of DOACs marked a significant advancement in anticoagulation, offering fixed dosing, fewer drug and food interactions, and reduced need for monitoring. DOACs have become the preferred treatment for most indications, including non-valvular atrial fibrillation, venous thromboembolism, and post-operative thromboprophylaxis. The future of anticoagulation lies in emerging therapies like Factor XI inhibitors and RNA- targeted agents, aiming to maintain efficacy while minimizing bleeding risk.Tétel Korlátozottan hozzáférhető A Review on the Potential Pharmacological Effects of Garlic, Soursop, and Avocado: Investigating the Mechanisms of Action and Clinical Benefits in Cardiovascular Health in the Ghanaian PopulationMaison , Effie; Pórszász, Róbert; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Halasi, Barbara Dóra; Szentmiklósi, József; Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet; Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThe effects of herbal medications such as garlic, avocado and soursop on cardiovascular health. Although clinically beneficial, they are limited by lack of standardisation and inappropriate dosage. Using a narrative review approach, peer-reviewed articles from databases such as PubMed, ScienceDirect, and AJOL were analysed to assess the phytochemical profiles, mechanisms of action, pharmacokinetics, and clinical relevance of these herbs. The findings show that garlic demonstrates antihypertensive, antiplatelet, and lipid-lowering properties primarily through ACE inhibition and nitric oxide enhancement. Soursop exhibits antioxidant effects and vasodilation but concerns about acetogenin-induced neurotoxicity limit its clinical use. Avocado offers lipid modulating and anti-inflammatory benefits which are supported by both dietary studies and dataTétel Korlátozottan hozzáférhető A scrape biopsy technique of the epidermis for DNA extraction from photoaging skin monitored by optical coherence tomography (OCT)Gross, Mor; Remenyik, Éva; Debreceni Egyetem::Általános Orvostudományi Kar::Bőrgyógyászati Tanszék; DE--Általános Orvostudományi Kar; Gellén, Emese; Csanádiné Galgóczi, Erika; Debreceni Egyetem::Általános Orvostudományi Kar::Bőrgyógyászati Tanszék; Debreceni Egyetem::Általános Orvostudományi Kar::Belgyógyászati IntézetSkin exposed to ultraviolet (UV) radiation might develop DNA damage and alterations in the epidermal layer, can lead to cancer. Extraction of genomic material for DNA analysis from epidermal layer in a non-invasive biopsy technique has a major role in skin cancer prediction. Scrape biopsy of the skin is a non-invasive, fast, and usually non-scaring method of epidermal layer sampling. Optical coherence tomography (OCT) in dermatology is used to identify skin structures, and allows monitoring skin damage following different procedures. The aims: To determine whether the quantity and quality of DNA isolation by scrap skin biopsy from patients with skin photoaging is suitable for DNA sequencing. In addition, to define the area and depth of biopsy using OCT device.Tétel Korlátozottan hozzáférhető Abdominal Compartment Syndrome with Respect to Acute PancreatitisAbdallah, Nadhem; Szentkereszty, Zsolt; Debreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézet; DE--Általános Orvostudományi Kar; Deák, Ádam; Kovács, Dávid; Debreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézet::Sebészeti Műtéttani Tanszék; Debreceni Egyetem::Általános Orvostudományi Kar::Sebészeti IntézetThis task was done in aim of reviewing the relevant literature pertaining to Intra Abdominal Hypertension and Abdominal Compartment Syndrome with a focused regard to the etiology of Acute Pancreatitis in order to gain the contemporary accepted definition, classification, pathophysiology, diagnosis and finally treatments of both IAH and ACS.Tétel Korlátozottan hozzáférhető Abnormal Vimentin and Histone H3p.K27me3 immunohistochemical expression patterns as potential surrogate markers for 1p/19q-codeletion in adult-type diffuse gliomasNinan, Rachael Suzanne; Bedekovics, Judit; Általános Orvostudományi Kar::Pathológiai Intézet; DE--Általános Orvostudományi KarThe retrospective study outlined in this thesis focuses on two adult-type diffuse gliomas - oligodendrogliomas and astrocytomas. Since both neoplasms possess several overlapping histological features, the identification of unique aberrations using molecular tests is essential for accurate diagnosis. However, these tests are generally less accessible and more expensive with longer turn-around times compared to immunohistochemical tests. The investigation aims to determine if variations in vimentin and histone H3p.K27me3 immunohistochemical expression could substitute for the 1p/19q-codeletion to effectively differentiate between the two gliomas. The correlation between these immunohistochemical stains and various histological features is also evaluated. Additionally, a review of the current literature pertaining to both central nervous system (CNS) tumors and the immunohistochemical markers is included.Tétel Korlátozottan hozzáférhető Abortive and prophylactic therapies in the treatment of migraineHassan, Henna; Pórszász, Róbert; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Drimba, László; Szentmiklósi, József András; Kenézy Kórház Aneszteziológiai és Intenziv Therápiás Osztály; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThis thesis looking into the production and management of migraine. An overview of the various theories that give rise to migraine. Acute management of migraine in relation to the theories. Understanding how many known drugs used for other comorbidities may influence the regression of migraine prophylactically. Along with an insight to herbal medication used in the therapy of migraine.Tétel Korlátozottan hozzáférhető About the pharmacological tools used in kidney transplantionAslan, Siran; Pórszász, Róbert; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Szentmiklósi, József András; Drimba, László; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Debreceni Egyetem::Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás TanszékIn my thesis, I aimed to focus on the type graft rejections, types of immunosuppressants and the complications that might occur. Such as azathriopoin , cyclosporin and Tacrolimus .Tétel Korlátozottan hozzáférhető Accelerated Partial Breast IrradiationNwidaa, Igwe Mecha; Furka, Andrea; Debreceni Egyetem::Általános Orvostudományi Kar::Onkológiai Intézet::Sugárterápia Tanszék; DE--Általános Orvostudományi Kar; Pintye, Éva; Dobos, Erik; Jósa András Oktatókórház, Nyíregyháza; Debreceni Egyetem::Általános Orvostudományi Kar::Onkológiai Intézet::Sugárterápia TanszékThe data from clinical trials investigating Accelerated Partial Breast Irradiation (APBI) have shown that with the proper patient selection, strict adherence to established guidelines and implementation of quality assurance procedures the efficacy outcomes using APBI are similar to those obtained using the conventional Whole Breast Irradiation (WBI) after breast-conserving surgery. The shorter treatment time with APBI could mean good implications for older patients, working women and patients who live far away from radiation therapy facilities and on the long run may prove to be a more cost-effective method of breast irradiation after breast-conserving surgery. Consequently, this is an indication that the desired rationale behind the implementation of a new method for radiotherapy has been achieved. The emergence of a new method of doing things did not render the previous method obsolete; it just offered patients the chance to have another option.Tétel Korlátozottan hozzáférhető Accelerated Partial Breast IrradiationEigbe, Zion; Furka, Andrea; Debreceni Egyetem::Általános Orvostudományi Kar::Onkológiai Intézet::Sugárterápia Tanszék; DE--Általános Orvostudományi Kar; Pintye, Éva; Hevesi, Erika; Jósa András Kórház; ScanoMed DebrecenAPBI has become the mainstay of breast cancer treatment. The short duration of therapy reduced total cost and positive result makes it a favourable option in the treatment of breast cancer.Tétel Korlátozottan hozzáférhető Ace inhibitors and cardiac remodeling in congestive heart failureAbu Ghazaleh, Mohammad; Pórszász, Róbert; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Drimba, László; Szentmiklósi, József András; Kenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztály; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThe thesis explains in detail the pathophysiology of heart failure and the role of Ace inhibitors in slowing the progression of heart failure by directly and indirectly slowing cardiac myocytes remodeling and ventricular hypertrophyTétel Korlátozottan hozzáférhető ACE inhibitors: therapeutic, pleiotropic effect and adverse reactions.Fahdawi, Othman Affan; Szentmiklósi, József András; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Drimba, László; Pórszász, Róbert; Kenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztály; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetAngiotensin-converting-enzyme inhibitors are a phmaceutical drugs used to treat several diseases such as hypertension and heart failure. During the passage of vessels in the lungs and renal vasculature, Ang I is generated by the action of renin on angiotensinogen which is then converted into Ang II by the action of an exopeptidase called ACE (Peter R et al., 1983). This is where ACE inhibitors comes into actions blocking the conversion of Ang I to Ang II. This conversion can be inhibited by angiotensin-converting enzyme inhibitors which results in vasodilation, decrease in blood volume which leads to a lower blood pressure and decrease in oxygen demand, reduction in Na retention and renin-angiotensin-aldosterone system activation (Chua D. et al., 2011). ACE inhibitors are categorised into two main groups, lower-affinity or plasma inhibitors and higher-affinity or tissue inhibitors. Some examples of ACE inhibitors include perindopril, quinapril, Ramipril, benazepril captopril, enalapril and Lisinopril (Krysiak R et al., 2008). Before administrating ACE inhibitors some precautions are required which include severe renal or cardiac failure, in case the patient is either hypovolemic or taking high- dose diuretic. Some indications of ACE inhibitors include hypertension, heart failure, and diabetes mellitus. Some contraindications include patients who have a history of hypersensitivity to any ACE inhibitor drugs or its components, angioedema, hypotension, pregnancy and current use of aliskiren in a patient with diabetes mellitus. Moreover, ACE inhibitors produce many beneficial effects, including regulation of smooth muscle cell proliferation and migration, anti-inflammatory, antioxidant effects and cytoprotection of vascular endothelium. Some of the adverse effects of ACE inhibitors include first-dose hypotension. Patients taking ACE inhibitors are more at risk for an abrupt fall in blood pressure after the first intake if they have high plasma renin before the treatment. Hyperkalaemia is another adverse effect which is defined a rise in plasma potassium after the intake of ACE inhibitor as a result of decrease in aldosterone secretion which in turn causes a decrease renal potassium excretion. ACE-induced angioedema has a low incidence of 0.1% to 0.2%, however, despite this its much feared due to its potentially life-threatening upper-airway obstruction most commonly in tongue or oropharynx (Vleeming W et al., 1998). Considering this, it is therefore of major importance that the physician is able to recognise these adverse effects, since a considerable percentage of patients are and will be under ACE inhibitor treatmentTétel Korlátozottan hozzáférhető ACE2 is a new potential target in the treatment of Cardiovascular diseasesRaja, Waasafa Aman Ullah Khan; Pórszász, Róbert; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Drimba, László; Megyeri, Attila; Debreceni Egyetem::Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetThe SARS-Covid 19 pandemic has hailed the spotlight on a relatively new component of the renin-angiotensin-aldosterone axis called ACE2, angiotensin converting enzyme 2. When scientists elaborated the pathophysiology of SARS-Covid 19, they discovered the viral receptor was ACE2. ACE2 is expressed on the apical surface of respiratory epithelial cells. This is initiated a plethora of studies that investigated the link between SARS-Covid19 and the renin-angiotensin-aldosterone-axis. ACE2 is not only the viral receptor for SARS-CoV-2, but it’s an important antagonist in the renin-angiotensin-aldosterone-axis. The renin-angiotensin-aldosterone axis is an important component of the cardiovascular system. It has been extensively studied for over a century in order to elucidate the physiological and therapeutic facets. Along with this study another arm of the RAS has been discovered, which is believed to bring about a counter-regulatory effect. The metabolic end-products of angiotensin I and angiotensin II are key players in cardiovascular physiology and pathophysiology. This non-canonical axis consists of angiotensin 1-7, angiotensin 1-9, angiotensin converting enzyme 2, the type 2 angiotensin II receptor (AT2R), the proto-oncogene Mas receptor and the Mas-related G-protein coupled receptor member D. Each of these component has been shown to counter-regulate the effects of the classical angiotensin system. This counter-regulatory renin-angiotensin system has a central role in the pathogenesis and development of various cardiovascular diseases. Indeed many animal studies have elaborated the cardio-protective effects of the components of the counter-regulatory RAS. Therefore they represent a potential therapeutic target in the management of cardiovascular disease. In this thesis we will demonstrate ACE2 in particular and elucidate how it is a potential target for the therapy of cardiovascular disease.Tétel Korlátozottan hozzáférhető ACL Tears in Children and AdolescentsThorrason, Valtyr Aron; Barkaszi, Árpád; Debreceni Egyetem::Általános Orvostudományi Kar::Traumatológiai és Kézsebészeti Tanszék; DE--Általános Orvostudományi Kar; Kiss, László; Turchányi, Béla; Debreceni Egyetem::Általános Orvostudományi Kar::Ortopédiai Klinika; Debreceni Egyetem::Általános Orvostudományi Kar::Traumatológiai és Kézsebészeti TanszékWith tears of the ACL in the youngest age groups occurring more frequently than ever, the demand has never been higher for prompt diagnosis and accurate management of ACL tears in children which takes into account the special complications which can arise in young individuals with open epiphyseal plates. This thesis is an overview of the pediatric-specific aspects of ACL tears, their diagnosis and management.Tétel Korlátozottan hozzáférhető Acne pathogenesis and treatmentShakeel, Areebah; Töröcsik, Dániel; Debreceni Egyetem::Általános Orvostudományi Kar::Bőrgyógyászati Klinika; DE--Általános Orvostudományi Kar; Szőllősi, Atilla; Oláh, Atilla; Debreceni Egyetem::Általános Orvostudományi Kar::Immunológiai Intézet; Debreceni Egyetem::Általános Orvostudományi Kar::Élettani IntézetAcne is a condition characterized by chronic inflammation of the pilosebaceous unit. The inflammation can be caused by abnormal keratinization which blocks the pore, excess sebum production, and the presence of Cutibacterium acnes (C. acnes). It mainly affects the adolescent population and can result in great psychological distress due to the lesions or the scarring. It ranges from mild to moderate to severe. Various treatment approaches are available including topical application of retinoids or antimicrobial drugs, another treatment approach is the systemic introduction of antibiotics or isotretinoin which is beneficial in topical resistant cases. However, the ideal approach should include psychotherapy along with medication to deal with body image distortion issues because of scars or lesions due to acneTétel Korlátozottan hozzáférhető Acne pathogenesis and treatmentTran Trieu, Phong; Töröcsik, Dániel; Debreceni Egyetem::Általános Orvostudományi Kar::Bőrgyógyászati Klinika; DE--Általános Orvostudományi Kar; Várvölgyi, Tünde; Szöllősi, Attila Gábor; Debreceni Egyetem::Általános Orvostudományi Kar::Bőrgyógyászati Klinika; Debreceni Egyetem::Általános Orvostudományi Kar::Élettani IntézetAcne is a skin condition featuring chronic inflammation of the pilosebaceous glands. It is the most common skin problem among teenagers and has been causing certain impacts in patient life quality. Acne is generally caused by seborrhea, hormonal alterations during puberty, abnormal keratinization, dysregulation of immune system, diet, and a change in the phylotypes of the colonizing Propionibacterium acnes. Different treatments are available, such as topical therapy, systemic therapy, or other alternative medications, despite the many efforts towards the understanding of acne pathogenesis and treatments standard guidelines with optimal acne remedies are still under debate.Tétel Korlátozottan hozzáférhető Acne treatment, facts and misconceptions.Naim, Pedram; Pórszász, Róbert; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Általános Orvostudományi Kar; Drimba, László; Szentmiklósi, József András; Kenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztály; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai IntézetAcne is a multifactorial and complicated dermatological condition, Due to it's complexity there lies many facts and fiction in it's pathology and treatment. This review aims to clarify and review the treatment options and ethiology.Tétel Korlátozottan hozzáférhető Acne; an overview of current and future treatment optionsFreidman, Hannah; Pórszász, Róbert; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; DE--Gyógyszerésztudományi Kar; Szentmiklósi, József András; Drimba, László; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Kenézy Kórház Központi Aneszteziológiai és Intezív Terápiás OsztályAcne is a common skin disease that affects most individuals at some point in their lives. It is classified into different forms which vary in severity, lesion type, and localization, with the face commonly involved. The hallmark of acne are comedones, which can develop further into inflammatory papules, pustules, or even abscesses and nodules. Symptoms typically begin in early puberty and cease spontaneously during the third decade of life. The are multiple etiological factors: genetic predisposition, seborrhea, and hyperkeratosis are known to promote the development of acne. Topical and systemic treatment options are available to counteract inflammation and hyperkeratosis, as well as to help purify the skin.Tétel Korlátozottan hozzáférhető Acute lower limb ischemia - reperfusion injuryDo, Trung Anh; Pető, Katalin; Department of Operative Techniques and Surgical Research; DE--Általános Orvostudományi Kar; Deák, Ádam; Kovács, Dávid Ágoston; Debreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézet::Sebészeti Műtéttani Tanszék; Debreceni Egyetem::Általános Orvostudományi Kar::Sebészeti IntézetAcute limb ischemia (ALI) occurs when there is a sudden reduction in limb perfusion due to an occlusion of peripheral arterial obstruction. The aim of the thesis is to give a brief overview on acute lower limb ischemia-reperfusion injury, involving etiology, pathophysiology and diagnostic possibilities, also highlighting the processes and consequences of ischemia-reperfusion injury in the background. Without early diagnosis and management, a patient with an embolic cause for an ischemic leg is at higher risk of death due to related underlying cardiac diseases, whereas a patient with a thrombotic cause is more likely to receive limb amputation.Tétel Korlátozottan hozzáférhető Acute Management Of Diabetic Ketoacidosis During ChildhoodDuong, Vo Nhu Y; Juhász, Éva; Debreceni Egyetem::Általános Orvostudományi Kar::Gyermekgyógyászati Intézet; DE--Általános Orvostudományi Kar; Grabicza, Anita; Bíró, Lajos; Debreceni Egyetem::Általános Orvostudományi Kar::Gyermekgyógyászati Intézet; Debreceni Egyetem::Általános Orvostudományi Kar::Sürgősségi Orvostani TanszékDiabetic ketoacidosis is a life-threatening complication of diabetes mellitus. It is commonly seen in diabetes mellitus type 1 but can also be present in diabetes mellitus type 2. Although diabetic ketoacidosis can be prevented, it is a frequent cause of mortality in children with type 1 diabetes mellitus. The management of diabetic ketoacidosis in children involves several strategies with the sole aim restoring the perfusion which will subsequently increase the uptake of glucose in the periphery, improve the glomerular filtration and counter the progressive acidosis. The treatment involves administration of insulin therapy, fluid and electrolyte rehydration, respiratory support as well as management of other complications. In addition, there are several complications of diabetic ketoacidosis which include cerebral oedema, pulmonary oedema, cardiac arrhythmias, aspiration of gastric contents, rhabdomyolysis etc.Tétel Korlátozottan hozzáférhető Adenosine and Adenosine Enhancers in Treatment of Cardiovascular DiseasesNoori, Mohammad Saeid; Szentmiklósi, József András; Department of Pharmacology; DE--Általános Orvostudományi Kar; Cseppentő, Ágnes; Takács, Ildikó; Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet; Debreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézet::Sebészeti Műtéttani TanszékAdenosine, the endogenous purine, through its action on four adenosine receptors, is involved in various processes in the heart, such as regulation of the oxygen demand, decrease in sympathetic tone, cell pre-conditioning, inflammation and angiogenesis. Four adenosine receptor subtypes mediate these effects: A1, A2A, A2B, and A3. These make adenosine and its receptor modulators a great candidate for reduction of morbidity and mortality in various cardiac diseases.