Theses (Faculty of Pharmacy)
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Tétel Korlátozottan hozzáférhető Comparative test of different antimicrobial preservatives for external pharmaceutical formulationsBoustanchi, Ali; Nemes, Dániel; DE--Gyógyszerésztudományi KarThis study explores the efficacy of antimicrobial preservatives in topical gels, following European Pharmacopoeia guidelines and Hungarian national formulary standards. Results indicate that benzoic and sorbic acid salts exhibit significant antimicrobial activity, making them promising alternatives to parabens. However, zinc gluconate and ethanolic solutions of methyl paraben showed limited efficacy. Surprisingly, the choice of gelling agent did not significantly affect the effectiveness of the tested materials. Overall, the study contributes to enhancing the safety and efficacy of external pharmaceutical formulations by addressing concerns about preservative toxicity and ensuring microbial stability throughout product shelf life.Tétel Korlátozottan hozzáférhető Pathogenesis and therapy of acne vulgarisAlshage, Kammla; Vasvári, Gábor; Tiszai, Dóra; Vasvári; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Ágnes, Rusznyák; Szabo, Erzsébet; Gyógyszerésztudományi KarAcne vulgaris, commonly referred to as acne, is a prevalent skin condition that typically begins in adolescence and can persist into adulthood. It manifests as various types of skin blemishes, including blackheads, whiteheads, pimples, and sometimes deeper cysts. The development of acne involves excess oil production, blockage of hair follicles, bacterial growth, and inflammation. Hormonal changes, particularly increased levels of androgens, can exacerbate the production of oil, contributing to more severe acne. Treatments for acne vary, ranging from topical creams to oral medications, depending on the severity of the condition. This thesis will explore the underlying causes of acne, its effects on individuals, and the various approaches to managing this widespread but complex skin disorder.Tétel Korlátozottan hozzáférhető Comparative test of different antimicrobial preservatives for external pharmaceutical formulationsBoustanchi, Ali; Nemes, Daniel; DE--Gyógyszerésztudományi KarThis thesis delves into the crucial role of antimicrobial preservatives in external pharmaceutical formulations, with a specific focus on their efficacy in topical gels. Through adherence to European Pharmacopoeia guidelines and referencing the Hungarian national formulary, Formulae Normales VIII, various preservatives were rigorously evaluated. Findings reveal that benzoic and sorbic acid salts exhibit notable antimicrobial activity, suggesting their viability over traditional options like methyl paraben. Importantly, this study underscores the significance of selecting appropriate preservatives regardless of the gelling agent, aiming to enhance both safety and efficacy while addressing concerns regarding preservative toxicity and ensuring microbial stability throughout product shelf life.Tétel Korlátozottan hozzáférhető Assessing the Impact of Transcutaneous Carbon Dioxide Therapy in Patients with Chronic Diseases and Concurrent Medications: A Comprehensive EvaluationNguyen, Thi Hong Ngoc; Tóth, Béla Ernő; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Bak, István; Váradi, Judit; Gyógyszerésztudományi KarMofetta therapy demonstrates potential as an effective approach for enhancing mobility, reducing dependency, uplifting mood, and augmenting quality of life. Moreover, recognizing Mofetta therapy as part of an integrative treatment plan rather than a standalone intervention is crucial. Despite existing limitations, Mofetta therapy holds promise for patients with musculoskeletal, joint, connective tissue, or circulatory disorders due to its efficacy. This dissertation aims to present the outcomes of Mofetta therapy intervention in 168 patients hospitalized with underlying diseases during 2021-2022, focusing on a comprehensive assessment encompassing physical and quality of life aspects. The study involved assessing various parameters before and after Mofetta therapy, including the 6-minute walk test (6MW), Timed Up and Go (TUG) test, Borg rating of perceived exertion, short form 36 health survey (SF-36), EuroQol 5 Dimensions 5 level version (EQ-5D-5L), EuroQol Visual Analog Scale (EQ-VAS), Functional Independence Measure (FIM), and Barthel Index.Tétel Korlátozottan hozzáférhető the synthesis of a new type of iminosugar analogues with morpholine backbone.abu, shadrach; hevesi-mezo, erika; DE--Gyógyszerésztudományi Kar; shadrachthis research was to synthesize new iminosugars analogs not described by the literature building upon research done by the department of pharmaceutical chemistry, employing reductive amination to synthesize fused and aliphatic morpholine derivatesTétel Korlátozottan hozzáférhető Pharmacological Evaluation of Newly Synthesised Cannabinoid Derivatives on H9c2 CellsJaved, Muhammad Bilal; Fesus, Adina; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; DE--Gyógyszerésztudományi KarILKA molecules are nationally developed cannabinoid and bixin containing derivatives with expected antioxidant effects. The aim of our study was to investigate whether pretreatment with ILKA 675 and ILKA 676 molecules has a protective effect against hypoxia-reoxygenation (H/R) induced acute injury on cardiac myocytes. In our series of experiments the H9c2 rat cardiomyoblast cells were treated for 24 hours and the IC50 values of the molecules were determined. After that, we investigated the cell viability using MTT assay. The concentration of 30 µM proved to be the most effective. Subsequently, this concentration was used to pretreat cardiomyocytes followed by four/three hours of H/R. The LDH assay was carried out to give information regarding the cytotoxicity of the molecules. Furthermore, antioxidant assays such as TEAC (Trolox Equivalent Antioxidant Capacity), FRAP (Ferric Reducing Antioxidant Power) and ORAC (Oxygen Radical Absorbance Capacity) were carried out to evaluate the antioxidant properties of the molecules. Our findings demonstrate that the pretreatment with the newly synthesised molecules significantly improved the cardiomyocytes viability after H/R. ILKA 675 was the least cytotoxic under hypoxic conditions. Furthermore, ILKA 675 showed the highest antioxidant activity according to the results obtained from the antioxidant assays. Overall, ILKA 675 and ILKA 676 may have a beneficial effect in the prevention of H/R induced cytotoxicity through the reduction of oxidative stress.Tétel Korlátozottan hozzáférhető Investigation of fluid-phase endoctosis of drug carrier cylodextrins on human cancer cell lines.Thanh Ngan, Pham; Fenyvesi, Ferenc; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Zsebik, Barbara; Horváth, László; Gyógyszerésztudományi Kar::Biofarmácia Tanszék; Gyógyszerésztudományi Kar::Gyógyszerfelügyelet és Gyógyszergazdálkodási TanszékThis research evaluates the endocytosis activity of nine specific cancer cell lines with two cyclodextrin derivatives: hydroxypropyl-B-cyclodextrin (HPBCD) and randomly- methylated--cyclodextrin (RAMEB). However, it is challenging to study cyclodextrins without conjugating with a fluorescent dye. Furthermore, different types of fluorescent labeling (Fluorescein and Rhodamine) affect the physicochemical properties of cyclodextrins distinctively, leading to variances in the cancer cell uptake process.Tétel Korlátozottan hozzáférhető Vaginal Candida Albicans Yeast InfectionOnoja, Ekoche Favour; Bácskay, Ildikó; Zsolt, Sinka Dávid; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Ujhelyi, Zoltán; Tóth, Zoltán; Gyógyszerésztudományi Kar::Gyógyszertechnológiai TanszékThis study investigates global experiences with vulvovaginal candidiasis (VVC), caused by Candida albicans. Through a web-based questionnaire, widespread awareness of VVC was observed, with common symptoms including itching, burning, and abnormal discharge. Treatment approaches varied, influenced by factors such as healthcare advice, personal experiences, age, education, and treatment goals. The findings underscore the need for tailored treatment approaches and preventive measures to mitigate recurrent VVC infections. This study offers valuable insights into the management of VVC among women worldwide.Tétel Korlátozottan hozzáférhető Nutritional Therapy of Premature BabiesNakate Semakadde , Jacqueline Vivian Nabakooza; Váradi, Judit; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; László , Horváth; Tóth-Klusóczki, Ágnes; Gyógyszerésztudományi Kar::Gyógyszertechnológiai TanszékPremature babies are more vulnerable to health issues due to their underdeveloped organs and immune systems. Providing proper nutrition is extremely important for their growth and health. This research focuses on the significance of nutrition in caring for premature babies, drawing from a thorough examination of existing studies. It highlights how early nutrition impacts the growth, brain development, and overall health of preterm infants. The review explores different nutritional methods like fortifying breast milk, using intravenous nutrition, and specialized preterm formulas to improve their nutritional status and health outcomes.Tétel Korlátozottan hozzáférhető Role of pharmacist in eczema therapy managementTajiki, Haniyeh; Bácskay, Ildikó; Sinka , Dávid; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Fehér, Pálma; Lekli, István; Gyógyszerésztudományi KarThis thesis looks at eczema, a common skin problem with no permanent cure. It tested three ointments with different amounts of salicylic acid to see which one works best for treating eczema. The ointments were tested for their texture and how well they penetrate skin. A survey was also given to people with eczema to understand their symptoms, triggers, treatments they've tried, and how eczema affects their daily life. The results were analyzed to find the most effective treatment option.Tétel Korlátozottan hozzáférhető Formulation and evaluation of diclofenac containing microcapsulesJokartangkarami, Mohammadreza; Jozsa, Liza; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Fesus, Adina; Nemes, DanielFormulation of diclofenac-containing microcapsules involves the encapsulation of diclofenac within a protective shell, typically made of biocompatible polymers, to enhance its stability and controlled release characteristics. The process often includes techniques such as emulsion solvent evaporation or interfacial polymerization to achieve uniform microcapsule size and drug distribution. Evaluation of these microcapsules encompasses various parameters including morphology, drug loading efficiency, encapsulation efficiency, in vitro drug release kinetics, and stability under different storage conditions. The performance of diclofenac microcapsules is crucially assessed for their potential therapeutic efficacy, bioavailability enhancement, and minimization of adverse effects, contributing to their applicability in pharmaceutical formulations for targeted and sustained drug delivery.Tétel Korlátozottan hozzáférhető Preformulation studies of curcumin with a PEG gamma cyclodextrin polymerKhalvati, Maria; Vasvári, Gábor; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Sinka, Dávid; Bakai-Bereczki, Ilona; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; Gyógyszerésztudományi Kar::Gyógyszerészi Kémiai TanszékThis study focuses on the ability of a PEG gamma cyclodextrin polymer to be a drug vehicle that may result in solubility and stability increase of poorly water-soluble drugs, such as curcumin. The study has been conducted due to the inability of curcumin to dissolve well in water, which also prevents its delivery and effectiveness as a drug. The problem of the research is the necessity of advanced drug delivery systems that help make poorly soluble and unstable drugs to be soluble. This technique involves the chemical incorporation of cyclodextrin and the incorporation of curcumin into the cyclodextrin chain. The in vitro studies were performed in order to examine the drug's efficiency in microparticles made of polymers as well as to understand the product compatibility of the polymer and PVA for delivery purposes. The study substantiated the most shown increase in curcumin solution that was encapsulated in the polymer along with the interaction of the polymer with mucin and the feasibility of PVA for the drug-carrying films. The research outcome could involve the design of indefinite-release dosage forms and extended-release medications for those drugs that are poorly soluble in water.Tétel Korlátozottan hozzáférhető Type II Diabetes MellitusOyeleke, Tomiwa Florence; Gyöngyösi , Alexandra; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Atilla, Czompa; Ildikó, Bácksay; Gyógyszerésztudományi KarType II Diabetes Mellitus is a chronic illness in which the body either produces insufficient insulin or fails to use insulin efficiently. In contract to Type I Diabetes Mellitus, Type II Diabetes Mellitus affects adults, although due to an increase in obesity, more and more cases are being identified in children and teenagers. Increased thirst, frequent urination, exhaustion, and weight loss are typical signs of type 2 diabetes. Eating a balanced diet, exercising frequently, and maintaining a healthy weight can help prevent or manage type II diabetes. Medication such as injectable insulin or oral hypoglycemics may occasionally be required to regulate blood sugar levels in people with Type II Diabetes.Tétel Korlátozottan hozzáférhető Formulation and Investigation of ointment containing lyophilized Viola Tricolor extractHojjati Saeidi, Shaghayegh; Jozsa, Liza; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Csepanyi, Evelin; Feher, PalmaThe thesis explores the dermatological effects of Viola tricolor, commonly known as wild pansy or heartsease. Viola tricolor has been traditionally used in herbal medicine for its potential benefits for the skin. The study investigates its anti-inflammatory, soothing, antioxidant, and antimicrobial properties and their potential applications in addressing various skin conditions such as eczema, dermatitis, and psoriasis. Through a review of existing literature and possibly some empirical research, the thesis aims to provide a comprehensive understanding of Viola tricolor's dermatological effects, contributing to the body of knowledge in natural skincare remedies.Tétel Korlátozottan hozzáférhető Synthesis of novel carbohydrate-isochromane derivativesMathew, Nithin; Borbás, Anikó; Kelemen, Viktor; Gyógyszerésztudományi Kar::Gyógyszerészi Kémiai Tanszék; DE--Gyógyszerésztudományi Kar; Árpád, Tósaki; Homolya, Ágnes; Gyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék; Gyógyszerésztudományi Kar::Gyógyszerészi Kémiai TanszékDiabetes mellitus is one of the most commonly occurring chronic, non-infectious diseases, potentially resulting in a multitude of serious, life-threatening complications if left untreated. There's been various treatments for this disease such as metformin for type 2 and subcutaneous insulin injections for type 1. Other treatments such as SGLT-2 inhibitors have been proven effective. The experiments aim to synthesize isochromane-carbohydrate derivatives that could potentially have both glycosidase inhibitory properties as well as act as SGLT-2 inhibitors using reactions oxa-Pictet-Spengler reaction and the photoinitiated thiol-ene addition reaction. Furthermore, these pharmacological and biological activities will be investigated with research collaborations.Tétel Korlátozottan hozzáférhető The role of antioxidants in selected chronic diseasesShirvani, Ali; Bak, Istvan; DE--Gyógyszerésztudományi Kar; Sinka, David; Vasvari, GaborThe thesis explores the correlation between oxidative stress, reactive oxygen species and the occurrence of various chronic illnesses and their pathomechanisms on a molecular level. The diseases which are stated are world leading causes of death such as, cardiovascular diseases, cancer, neurodegenerative conditions such as Alzheimer’s disease and diabetes mellitus. The pathways which oxidative stress can induce or exacerbate the aforementioned conditions is explained and analyzed. The positive influence of antioxidants and the possibility of antioxidant therapy and its clinical approach is also discussed.Tétel Korlátozottan hozzáférhető Novels and New Therapeutic Options in Gluten-Related DiseasesOkafor-osadebe , Chukwudalu; Váradi, Judit; DE--Gyógyszerésztudományi Kar; Dobos , Nikoletta; Bácskay, IldikóWith a focus on celiac disease, the thesis Novels and New Therapeutic Options in Gluten-Related Diseases offers a thorough summary of all gluten-related illnesses. It addresses subjects like the components and structure of wheat grains, the aetiology of celiac disease, and possible treatments. The paper examines cutting-edge approaches to gluten sensitivity, such as the use of enzymes and vaccinations. All things considered, the thesis provides insightful information about the recognition and treatment of gluten-related illnesses and provides a preview of new therapeutic approaches in this area.Tétel Korlátozottan hozzáférhető Optimizing Pharmacotherapy for Diabetes Mellitus, A comprehensive analysis of drug classes and treatment approaches.Khamboo, Aliyah; Pórszász, Róbert; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi Kar; Szentmiklósi, József; Gyógyszerésztudományi KarOptimizing pharmacotherapy for diabetes mellitus is a complex process that requires careful evaluation of the wide variety of medication classes and possible therapeutic approaches. Through careful assessment of the safety profile, effectiveness, and unique requirements of each patient, medical professionals can customize treatment plans to minimize the risk of diabetes-related long-term problems while simultaneously achieving ideal glycemic control. By tailoring treatment regimens to each person's particular circumstances and preferences, this patient-centered approach improves adherence and the overall success of treatment.Tétel Korlátozottan hozzáférhető Comparison of dissolution profiles of matrix tabletsMengenli, Akay Dogan; Vasvári , Gábor; Gyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék; DE--Gyógyszerésztudományi Kar; Fenyvesi , Ferenc; Hevesi-Mező , Erika; Gyógyszerésztudományi Kar; Gyógyszerésztudományi Kar::Gyógyszerészi Kémiai TanszékThe goal of thesis was to create tablets with metronidazole as the API (active pharmaceutical ingredient) that performed well in 3 major tests: hardness, friability, and dissolution. Five different tablet compositions were prepared and compressed using a single-punch tablet press, varying in contents of: ethyl cellulose and microcrystalline cellulose. After comparing the physical properties of the drug compositions with drug dissolution profiles, it was found that formulation 4 showed optimal results. Tablets from formulation 4 had suitable weight, did not crack or collapse during hardness and friability tests, and exhibited desirable dissolution characteristics. As a result of the experiment, it was found that the ratio of ethyl cellulose to microcrystalline cellulose is crucial in formulating hydrophobic matrices via direct compression, with an optimal ratio of 1:1. Also, to achieve optimal prolonged release of the drug, the hydrophobic polymer should be added in a 1:2 ratio in comparison with the API (active pharmaceutical ingredient). In summary, the experiment identified an optimal tablet formulation (formulation 4) and highlighted the importance of specific ratios of cellulose derivatives for desired tablet properties and drug release profiles.Tétel Korlátozottan hozzáférhető Formulation and evaluation of spray dryed diclofenac nanoparticlesHomayounkia, Yasaman; Ujhelyi , Zoltán; Gyógyszerésztudományi Kar; DE--Gyógyszerésztudományi KarThis study provides a comprehensive overview of nanoparticles in pharmaceuticals, emphasizing their pivotal role in modern pharmaceutics. It explores the Buchi B90 spray drying device using materials like PVA, PLA, mannitol, and sorbitol to create nanoparticles, with PVA emerging as the most promising material. The research evaluates nanoparticle characteristics through Particle Size Analysis and Dynamic Light Scattering, confirming successful production with desirable properties for various applications. It highlights the spray drying technique’s potential as a versatile platform for nanoparticle synthesis and underscores PVA’s crucial role in facilitating particle formation. Overall, this research expands understanding and practical application of nanoparticles in drug delivery systems and related fields, showcasing their significant impact in modern pharmaceutics.